Metabolic Disorder Articles & Analysis: Older
25 articles found
They are implicated in a wide range of conditions, from cardiovascular and metabolic disorders to neurological diseases and cancers. By facilitating the early stages of the drug development pipeline, GPCR Screening Services help streamline the identification of lead compounds, optimizing the chances of successful therapeutic outcomes. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA targets. ...
Beyond their roles in blood flow regulation and inflammation, SMECs contribute to metabolic functions within skeletal muscle. They participate in the uptake and delivery of glucose and fatty acids, influencing the metabolic state of the muscle. This function is particularly important in the context of metabolic disorders such as ...
They have shown great potential in treating various diseases, such as cancer, autoimmune diseases, infectious diseases, and metabolic disorders. However, to ensure the safety and efficacy of these drugs, strict quality control and characterization are necessary. ...
Peptidomimetics can also stabilize secondary structures, such as alpha-helices or beta-sheets, which are critical for the function of proteins and increase the stability and potency of therapeutic peptides.Peptidomimetics ResearchPeptidomimetics have been successfully developed for a wide range of therapeutic applications, including cancer, infectious diseases, and metabolism ...
Spectroscopic MethodsInfrared spectroscopy and Raman spectroscopy can also be used to analyze the glycation structure and changes of collagen.These methods can be used separately or in combination to obtain a comprehensive understanding of the structure and function of glycated collagen.The detection of glycated collagen is also one of the methods used to assess diabetes and glucose ...
Consequently, prolidase deficiency has been linked to various medical conditions, including skin disorders, chronic wounds, and certain genetic disorders. In the pharmaceutical and nutraceutical sectors, Native Porcine Prolidase is used as a dietary supplement to support skin health, wound healing, and collagen synthesis. ...
Many abnormal physiological states are associated with disorders of lipid metabolism. Studying the changes of lipids in different states of the organism at the systemic level can help analyze the mechanisms of lipid metabolic networks. ...
Sleep apnea is a severe sleeping disorder in which a person experiences interruptive breathing or loud snoring. Long-term untreated or undiagnosed sleep apnea can cause several health problems, such as daytime sleepiness, cognitive impairment, fatigue, and metabolic disorders. The development of groundbreaking sleep apnea devices, including ...
This process occurs in plants through photosynthesis and in animals through various metabolic pathways. The synthesis of carbohydrates involves a series of enzymatic reactions that convert simple molecules into more complex structures. ...
These oral antidiabetic medications mainly work by increasing insulin sensitivity, slowing down the metabolism of carbohydrates in the small intestine, repairing and improving the function of pancreatic β-cells, and promoting insulin secretion to achieve blood glucose reduction. ...
Rare diseases, also known as orphan diseases, are a diverse group of disorders that affect a small percentage of the population. Due to their low prevalence and limited understanding, treating and finding cures for these conditions present significant challenges. ...
Diabetes Models Broadly, diabetes models offer an effective tool to study the multidimensional nature of this metabolic disorder. These models include in vivo animal models, in vitro cell culture models, in silico (computer-based) models, and genetically modified organism models. ...
Pharmaceutical Industry: In pharmaceuticals, α-Galactosidase plays a vital role in the development of medications targeting digestive health and metabolic disorders. The goal is to increase the efficacy of these medications for better patient outcomes. ...
The precise modification of peptides through bioconjugation provides opportunities for the development of peptide-based therapeutics targeting cancer, neurodegenerative disorders, or metabolic diseases. Peptide RNA conjugation: It refers to the process of attaching a therapeutic peptide molecule to an RNA molecule to create a novel therapeutic entity. ...
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence ...
It revealed a novel mechanism by which the deubiquitinosomal system senses metabolic signals such as glucose and fatty acids and regulates energy metabolism. ...
This question is answered in a recent publication published in Cell Metabolism. Researchers discovered, using a mouse model, that exercise at different times of the day has varied impacts on local and systemic metabolism. ...
Secukinumab, an IL-17A sequestering agent used in treating psoriasis, was selected as a repurposed candidate to address the sequential inflammatory disorders that follow the first metabolic insult. Conclusions Our analysis suggests this novel combinatorial therapeutic approach inducing DPP4 and Il-17a suppression has a high likelihood of ameliorating a ...
In addition, scientists have recently discovered that CC fruit also exerts protective prebiotic effects by increasing the abundance of mucinophilic Akkermansia and Bifidobacterium in the intestine to alleviate obesity and associated metabolic disorders in mice. In this study, we discovered that combining CC with anti-PD-1 therapy reduced tumor growth more ...