Metabolic Disorder Articles & Analysis: This-Year
8 articles found
Why Their Analysis is Critical Because sterols are central to so many biological processes, the ability to accurately measure them is paramount. When sterol metabolism goes awry, it can have serious consequences. For example, imbalances in cholesterol transport and metabolism are directly linked to atherosclerosis and heart disease. ...
Thousands of non-histone proteins are also targets of lysine acetylation. This includes: Metabolic Enzymes: Acetylation can directly regulate the activity of key enzymes involved in glycolysis, gluconeogenesis, and fatty acid metabolism, linking cellular energy status (via acetyl-CoA levels) directly to metabolic control. ...
TCA Cycle Analysis in Research Recent advancements in metabolomics have shed light on the importance of TCA Cycle analysis in various fields of research, including cancer biology, cardiovascular health, and metabolic disorders. By examining the levels of TCA Cycle intermediates and associated metabolites, scientists can gain insights into cellular ...
Disease Modeling: Custom knockout cell lines can mimic specific diseases by disabling genes associated with particular disorders. This modeling can be invaluable for studying the pathophysiology of diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. ...
An imbalance of NAD⁺ and NADH levels can lead to metabolic disorders and oxidative stress. Biosynthesis and Signaling: Beyond redox reactions, NAD⁺ also acts as a substrate for enzymes like sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, which regulate DNA repair, aging, and cell signaling. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. ...
One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular activities and metabolic dynamics of living systems. ...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. Understanding this condition is crucial for effective intervention and treatment. ...