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Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be ...
Tissue Sections and Immunofluorescence StainingUsing specific anti-collagen antibodies to stain tissue sections, and then observing with a fluorescence microscope, collagen can be located and quantified at the tissue level.2. Confocal Microscopy or Electron MicroscopyThese higher resolution imaging techniques can be used to observe the distribution and structure of collagen at ...
Cytoskeleton Technologies ·High-Resolution Microscopy The development of advanced microscopy techniques, such as super-resolution microscopy (e.g., STORM, PALM), has drastically improved our ability to visualize the cytoskeleton. ...
Structural biology techniques, such as X-ray crystallography and cryo-electron microscopy, are providing unprecedented insights into RNase function and guiding the rational design of modified enzymes. ...
Currently, DNA constructs encoding fluorescent proteins fused to LC3 are widely employed for introduction into cells for monitoring autophagosome formation by fluorescence microscopy. QVirus™ Platform has launched series of lentiviral packaging service of autophagy related biosensors, in which GFP and/or RFP tags are fused at the C-termini of the autophagosome marker LC3, ...
Despite the abundant content of collagen, accounting for about 30% of total body protein, it may be difficult to purify and analyze. This is due to collagen molecules forming an extensive network through different types of cross-linking, making the collagen molecules insoluble and difficult to extract.At present, several types of analysis methods are available for collagen analysis:ELISA of ...
Introduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. Variant detection and analysis refer to the sequencing and difference analysis of a genome ...
Techniques like dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) are used to analyze the size, shape, and surface properties of the nanoparticles. ...
Simultaneously, advancements in structural biology, including X-ray crystallography and cryo-electron microscopy, provide unprecedented insights into the three-dimensional structures of target proteins and their interactions with potential drug molecules. ...
One such assay is the fluorescent microscopy-based analysis of cell nuclei and mitochondria, where apoptotic cells exhibit condensed and fragmented nuclei, along with altered mitochondrial membrane potential. ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology. This technology involves the use of microscopic particles to deliver drugs in a controlled and sustained manner over an extended period of time. By encapsulating drugs within these microspheres, pharmaceutical companies ...
Do you sneeze, cough, and have itchy eyes after cleaning your house or coming into contact with dust? Then, You could have a dust allergy, a common illness. When you think about allergies, you might think of pollen or pet dander. However, another prevalent cause that often goes undiscovered is dust allergies. Dust allergies are among the most pervasive indoor allergens today. While not ...
Traditionally, researchers have relied on experimental techniques like X-ray crystallography and cryo-electron microscopy to solve the structures of enzymes. However, these methods can be time-consuming and often require large quantities of purified protein samples. ...
The backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film-forming material to support the microneedle fractions, so that the backing layer has a tight bond with the microneedle tip, and the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, without the problem of process ...
Temperature, concentration and mixing rate are factors that affect the physicochemical properties of the adjuvant produced. Electron microscopy reveals that the AH adjuvant consists of nanoparticle fibers that form loose particulate aggregates. ...
Imagine tiny bubbles, smaller than a red blood cell, carrying powerful medicines directly to diseased cells. This isn't science fiction, it's the cutting edge of drug delivery with drug-loaded liposomes. What are liposomes? Liposomes are microscopic spheres made from phospholipids, the same fatty molecules that make up cell membranes. These phospholipids naturally arrange themselves in ...
These dyes emit light when excited by specific wavelengths, allowing researchers to visualize the liposomes in real-time using fluorescence microscopy or other imaging techniques. Benefits of fluorescent liposomes Real-time tracking: Researchers can observe the movement of liposomes within tissues and organs, understanding their uptake by cells, biodistribution, and potential ...
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its innovative line of Chromogenic Substrates for immunohistochemistry (IHC). These cutting-edge substrates offer superior signal sensitivity, long-term storage stability, enhanced safety, and user-friendliness, empowering researchers to unlock deeper insights into ...