mitochondrial membrane Articles
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Septins stabilize mitochondria in tetrahymena thermophila
We describe phylogenetic and functional studies of three septins in the free-living ciliate Tetrahymena thermophila. Both deletion and overproduction of septins led to vacuolization of mitochondria, destabilization of the nuclear envelope, and increased autophagy. All three green fluorescent protein-tagged septins localized to mitochondria. Specific septins localized to the outer mitochondrial ...
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Pet191 is a cytochrome c oxidase assembly factor in saccharomyces cerevisiae
The twin-Cx9C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx9C motif class of proteins in being independent of the Mia40 ...
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Cadmium inhibits the vitellogenesis of freshwater crab Sinopotamon henanense
Cadmium (Cd) may pose risks to freshwater organisms, including crabs that live at the interface of sediments and water column all year round. One of the major changes that occur during oocyte maturation of crabs is the production of vitellin (Vn). In the present study, we investigated the effects of Cd on oocyte size, Vn level, and vitellogenin (Vg) mRNA expression in the ovary of the ...
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Mitochondrial Proteins
Mitochondria are dynamic organelles with bilayer membranes. Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health ...
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Advanced Proximity Labeling Techniques
Proximity labeling techniques represent a cutting-edge approach wherein a decoy protein of interest is fused with an enzyme capable of indiscriminately labeling neighboring proteins. These labeled proteins are referred to as "prey" proteins. The field of protein labeling has witnessed significant advancements, prominently featuring proximity-tagging enzymes. Among these, Biotin-dependent biotin ...
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Cytochrome P450: A Vital Biosynthetic Enzymes for Drug Metabolism
Overview of Cytochrome P450 Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various compounds as well as in the synthesis and breakdown of hormones. In plants, they regulate the synthesis of defense compounds, fatty acids, and hormones. With the progress ...
By BOC Sciences
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Fatty Acids in Cancer
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
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In Vitro Inhalation Testing: Revolutionizing Inhalation Product Safety
In the world of product safety and environmental health, assessing potential risks associated with inhalable products has always been a complex challenge. Commercial nebulizer applications, used for various purposes like disinfection and scenting, release potentially harmful aerosols into the air. Understanding the possible adverse acute inhalation effects of these aerosols is crucial for ...
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Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
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