Refine by
Neurodegenerative Articles & Analysis: Older
63 articles found
These projects involve a variety of disease targets, including cancer, inflammation, and neurodegenerative diseases. Frontier CRO companies like Alfa Chemistry are actively developing their wide range of PROTAC building block product lines. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA targets. ...
This characteristic is being explored in the treatment of conditions such as osteoarthritis, cardiovascular diseases, and neurodegenerative disorders. Immunomodulation: These cells exhibit immunomodulatory properties, which means they can influence the immune response. ...
For instance, some differentially expressed proteins may be associated with disease progression, drug responses, or cellular stress responses.ApplicationsResearch on differentially expressed proteins has applications in many fields, including cancer, neurodegenerative diseases, metabolic diseases, etc. Moreover, they can serve as disease biomarkers or drug targets.Studying ...
Disease Mechanism ResearchProtein phosphorylation plays crucial roles in many diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Studying changes in protein phosphorylation in these diseases can help reveal the molecular mechanisms of these conditions.3. ...
For specific acetylation site localization, mass spectrometry is usually the preferred method.Changes in the acetylation level of a specific protein are related to the development of various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Therefore, acetylation detection has potential application value in early disease diagnosis and treatment ...
Disease MechanismsStudy changes in oxidative phosphorylation in various diseases (such as neurodegenerative diseases, cancer).3. Drug Screening and Toxicity TestingEvaluate the impact of drugs on mitochondrial function.Precautions1. ...
Moreover, glycoproteins are involved in the onset and progression of many diseases, such as cancer, diabetes, neurodegenerative diseases, etc.What Is the TAP Detection Method?The TAP detection method is a quantitative detection method for glycoproteins. ...
Furthermore, changes in the mitochondrial proteome may be associated with certain diseases, including neurodegenerative diseases, cancer, heart disease, diabetes, and genetic disorders.Methods of Mitochondrial Protein SequencingMitochondrial protein sequencing typically involves the following steps: firstly, scientists need to extract the mitochondria from cells and isolate the ...
In the nervous system, abnormal TNC protein levels have been linked to neurodegenerative diseases like Alzheimer's and Parkinson's. Research suggests it may influence the deposition of harmful protein aggregates that are a hallmark of these disorders. ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of post-translational ...
Disease Relevance Abnormal ubiquitination processes are closely related to various diseases, including cancers, neurodegenerative diseases, and inflammatory diseases. 2. Drug Targets Understanding ubiquitination sites is significant for developing drugs targeting specific proteins, especially in cancer treatment. 3. ...
Ubiquitination detection contributes to a better understanding of the role of ubiquitination in cellular physiological and pathological processes, particularly in studying protein degradation, signal transduction disorders, and molecular mechanisms associated with various diseases such as cancer and neurodegenerative diseases. ...
Disease Relevance Abnormalities in ubiquitination sites, whether due to mutation or imbalance in regulation, are associated with the development and progression of various diseases, including cancer, neurodegenerative diseases, immune system diseases, etc. 3. Drug Target Ubiquitination sites and their related enzymes (such as E3 ubiquitin ligase) are potential drug targets. ...
These post-translational modifications are not only vital for cell function, but their abnormal changes are also associated with cancer, neurodegenerative diseases, and other pathological conditions. Therefore, research on histone PTMs can help to deepen our understanding of disease mechanisms and develop new therapeutic strategies. ...
SUMOylation and Diseases Abnormal SUMOylation is associated with various diseases, including cancer, neurodegenerative diseases and cardiovascular diseases. Therefore, studying the SUMOylation of histones is crucial for understanding the molecular mechanisms of these diseases. 2. ...
Pathological States Abnormal patterns of histone phosphorylation are associated with various diseases (such as cancer, neurodegenerative diseases) and can lead to dysregulation of gene expression and abnormal cellular ...
Cellular metabolism is the general term for the ordered series of chemical reactions that occur within cells to sustain life. These reactive processes allow organisms to grow and reproduce, maintain their structure, and respond to the external environment. Metabolism is usually divided into two categories: catabolism, which breaks down large molecules for energy (e.g., cellular respiration), ...
Researchers are exploring how to use these glowing biopolymers to study the progression of neurodegenerative diseases like Alzheimer's and Parkinson's at the molecular level. ...
ByMatexcel