Nk Cells Articles & Analysis
39 articles found
They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced ...
Several studies have shown that CpG ODN is able to stimulate cells that express TLR9, initiating an immunomodulatory cascade that culminates in the production of Th1 and proinflammatory cytokines and chemokines. Besides, they also can improve the antigen presenting function of dendritic cells, monocytes and macrophages, induce the proliferation of B ...
What are Adjuvants? Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. ...
This cutting-edge technology holds great potential in treating diseases through targeted drug delivery. CAR-T/CAR-NK Cells Development for Drug Delivery Systems As a groundbreaking advancement in immunotherapy, CAR-T (Chimeric Antigen Receptor T-cell) and CAR-NK (Chimeric Antigen Receptor Natural Killer) ...
It achieves this by binding to the adenosine A2A receptor (ADORA2A), which is expressed by various immune cells like T cells, natural killer (NK) cells, and dendritic cells (DCs). ...
The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses, which are part of the body's natural defense system. ...
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. ...
These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. ...
Introduction to CADM Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. ...
Researchers state that enoblituzumab, as a new treatment approach, primarily works by relieving the inhibition of the immune system's recognition and elimination of cancer cells by B7-H3. It triggers the physiological process of antibody-dependent cell cytotoxicity (ADCC), activating cytotoxic immune cells such as macrophages and natural killer ...
IL-17D IL-17D is expressed in many cells and organs, but its expression in immune cells such as lymphocytes and monocytes is weak. IL-17D induces endothelial cells to produce IL-6, IL-8, and GM-CSF. It also has an inhibitory effect on hematopoiesis of bone marrow precursor cells. Other studies suggest that IL-17D is associated ...
Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. ...
Below is an overview of the main players in the immune system, showing selected synergies amongst various cell types. As seen in the graph below, some cells play a more central role than others; T helper cells for example are a key link between the cellular adaptive response and the humoral adaptive response (you can find out more about T helper ...
For example, matrix-targeting ADC drugs have the potential to cause cancer cell death by reducing the concentration of growth factors produced by matrix-resident cells. ...
The overexpression of mesothelin in ovarian cancer cells has a similar effect and is significantly correlated with the expression of MMP-7. In addition, mesothelin binding to CA125/MUC16 also triggers the expression of MMP-7 through the p38 MAPK pathway in pancreatic ductal adenocarcinoma. In addition, pancreatic cancer cell lines overexpressing mesothelin ...
Abstract Natural killer (NK) cells are emerging as a new tool for cell therapy of cancer. However, some cancer subtypes are relatively resistant to NK cell cytotoxicity. Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
In hematological malignancies, complete response rates to CAR-T cells can exceed 80%. These responses are often durable in nature and have attracted considerable excitement and investment in the development of cell therapies for an expanded range of indications, particularly in solid tumors. ...
Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell growth and differentiation, modulate immune response ...
AFM13 is a first-in-class tetravalent, bispecific NK cell engager that binds to CD30 on tumor cells and CD16A on NK cells. By engaging CD16-positive NK cells, AFM13 leads to NK cell-mediated killing of tumor cells.1 Pembrolizumab ...