Oral Dosing Articles & Analysis
6 articles found
Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal side effects and liver toxicity. ...
Rani Therapeutics, a clinical-stage biotherapeutics company, based in San Jose, CA, is developing orally-administered biologics. Their novel, patented platform technology replaces subcutaneous or IV injection of biologics with oral dosing. The RaniPill capsule is an orally ingestible vehicle, approximately the size of a standard ...
Rani Therapeutics could offer an easier alternative for people to home-dose by taking a pill instead of injections. The RaniPill capsule is the company’s patented platform technology that is designed to replace subcutaneous or IV injections of biologics with oral dosing. ...
Rani, A Platform Technology Company: Rani's proprietary platform technology, the RaniPill capsule, intends to replace subcutaneous or intravenous injections of biologics with oral dosing. RaniPill helps convert injectable biologic drugs such as TNF-alpha inhibitors, interleukin antibodies and basal insulin, among others, into pills. ...
Plasma and brain cholinesterase activity in relation to time since exposure to pesticide were also determined. An orally applied dose of 90 mg kg−1 fenitrothion reduced running endurance in the stripe‐faced dunnart, Sminthopsis macroura, by 80% the day after exposure concomitantly with a reduction of approximately (∼) 50% in plasma and 45% in brain ...
Twenty five-week old hens (n = 6) were administered with an oral dose of 75 mg of Oxytetracycline (OTC) hydrochloride per day per head for five consecutive days and its residues in eggs as well as breast, leg and liver tissues were analysed by a high-performance liquid chromatography-ultraviolet visible detection (HPLC-UV) technique. The highest OTC residue ...