Peptide Antigen Articles & Analysis
9 articles found
The Unique Value and Challenges of Peptide Antigens in Antibody DiscoveryChoosing the right antigen is crucial in antibody discovery. ...
Antimicrobial peptides, also known as host defense peptides, serve as frontline warriors in our immune system. ...
In this paper, CMV antigenic peptide epitopes are employed, with peptides that have been proven to be functional and more generic for CMV-CTL. ...
T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those expressed by cancer cells. αβ T cells are the effector cells of adaptive immunity, which exert cytotoxicity in a major histocompatibility complex (MHC)-restricted manner. ...
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? ...
Recently, researchers at Notre Dame University have identified specific features of the reaction of two distinct peptide antigens to a T-cell receptor (TCR), which provides new clues to optimizing molecular structure for the development of immunotherapy of cancer cell research. ...
Chimeric antigen receptor T-cells (CAR-T) are one of the first clinically approved therapies to take full advantage of the most significant advancements in immunology and genetic engineering. The resulting therapeutics have been shown to produce remission rates exceeding 80% in patients with CD19+ B-cell lymphoma, making them nothing short of remarkable [1]. Unfortunately, CAR-T cells seem ...
Although the best-defined function of type II major histocompatibility complex (MHC-II) is presentation of antigenic peptides to T lymphocytes, these molecules can also transduce signals leading alternatively to cell activation or apoptotic death. ...
Many HIV-1 envelope-based synthetic peptides behave as antigenic mimics of linear or conformational epitopes generated in vivo in infected subjects, meaning they can be used as immunogens for antibody induction in appropriate animal models or as antigens in Enzyme-Linked Immunosorbent Assay (ELISA). These peptides are linear or ...