Preclinical Testing Articles & Analysis: Older
85 articles found
Alfa Cytology has unveiled new services focused on therapeutic antibody development for bladder cancer research.Alfa Cytology, a prominent cancer research services supplier based in New York, proudly announces the launch of its comprehensive services for bladder cancer therapeutic antibody development. This initiative represents a critical advancement in pursuing effective bladder cancer ...
Tumor models for breast cancer, which include both in vivo and in vitro systems, are crucial for studying the complexities of tumor biology and testing potential treatments. These models allow researchers to mimic the tumor microenvironment, providing insights into the behavior of cancer cells, their interactions with surrounding tissues, and their responses to various ...
In recent years, adeno-associated virus (AAV) particles have emerged as a pivotal tool in the realm of gene therapy, offering researchers and clinicians innovative approaches to treat a variety of genetic disorders. Premade AAV particles represent a significant advancement in this field, streamlining the process of gene delivery and significantly enhancing the efficiency and efficacy of ...
By utilizing a wide array of methodologies, from molecular-targeted drug design to customized testing platforms, Alfa Cytology’s solutions enable researchers to address the complexities of brain cancer pathogenesis and discover novel therapeutic targets. ...
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
Despite more stringent manufacturing processes and analytical testing, there may be little variation between proteins in vials. It's perfectly valid to ask whether the manufacturing steps and materials used are essentially the same. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
CD BioSciences, a biotech company specializing in centrosomal study, has recently launched new services for anti-centrosome antibody development. The services help identify and track centrosomes in experiments, demonstrating the strength of anti-centrosome antibodies as a great tool for centrosome research. The centrosome is a key cellular structure that plays a crucial role in the organization ...
Applicability of Animal ModelsIn the process of antibody discovery, the use of in vivo models is often limited by the applicability of animal models, which can cause trouble for early development and subsequent testing. Especially when the host's own tissues express target antigens, the phenomenon of immune tolerance may hinder the stimulation of effective immune responses, ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
Alfa Cytology has announced its small molecule drug development to advance preclinical cancer research. Alfa Cytology, a comprehensive biotech company specializing in cancer research, has recently announced the cancer small molecule drug development services. ...
These models help analyze molecular characteristics, control cell culture conditions, and facilitate functional testing. Moreover, they can further elucidate the targets and provide an effective environment for developing new drugs. ...
Although it is generally believed that HCP can potentially trigger an immune response and constitute a clinical safety risk, it is difficult to prove which HCP and concentration may cause immunogenicity problems. Theoretically, preclinical pharmacological and toxicological evaluations can be performed in the presence of different amounts of HCP impurities. ...
These studies typically involve testing the drug in cell cultures and animal models to assess its ability to target and shrink or destroy cells in the excreta. ...
As a leading biotechnology company, MtoZ Biolabs is committed to providing comprehensive, one-stop CRO testing services to scientific research institutions and pharmaceutical companies worldwide. Whether in the early stages of drug discovery, candidate drug evaluation, or preclinical development, MtoZ Biolabs can provide professional technical support and ...
Once hybridoma cells that produce test antibodies are connected, they can grow in the culture and produce a large amount of antibodies. ...
Quality Control of Aluminum-adjuvanted Vaccines First, the nature of the surface charge of aluminum-adsorbed antigens needs to be understood in order to predict the physical properties of vaccine suspensions; Second, determining the rate and strength of adsorption of aluminum adsorbed antigens can help us to understand the ability of aluminum adjuvants to adsorb antigens, as well as their ...
In addition, there is currently no unified CMC declaration format for ADC products in the world, and sponsors cannot create globally applicable documents.Monoclonal Antibody (mAb)Regulatory requirements for ADC antibody intermediates and their use as final DS are consistent, and comparable studies between preclinical materials and clinical materials should be conducted in terms ...
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. Bispecific antibody conjugates (BsAb ADCs) are one of the emerging new technologies. The high specificity of bispecific antibodies enables more precise targeting of tumor cells. On the other ...
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...