Therapeutics Cell Articles & Analysis
22 articles found
Their nanoscale size, biocompatibility, and ability to encapsulate therapeutic agents make them suitable carriers for both small molecules and larger biomolecules like proteins and nucleic acids. VLPs can improve the bioavailability and stability of drugs while enabling targeted delivery to specific tissues or cells, thus enhancing therapeutic ...
These cells have garnered significant attention in the field of regenerative medicine and therapeutic research due to their unique properties and potential applications. ...
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are ...
Nanobodies can be engineered to specifically target tissues or cells of interest by conjugating them to therapeutic agents. This targeting ability minimizes off-target effects and increases the efficacy of the drug. For example, nanobodies have been successfully used to deliver chemotherapeutic agents to tumor cells, resulting in improved cancer ...
Pancreatic cancer is one kind of cancer that originates from the pancreas, an important organ behind the stomach. When cells in the pancreas grow uncontrollably, they can form tumors and trigger cancer. ...
AAV vectors are used as delivery vehicles or "vectors" to administer therapeutic genes into patient's cells. This therapeutic gene, once inside the cell, generates a functional protein to correct or counter the effects of the disease-causing genetic mutation, providing a basis for curing several genetic diseases. ...
These linkers are designed to be stable in circulation but release cytotoxicity upon internalization by target cancer cells, ensuring maximum therapeutic efficacy while minimizing off-target toxicity.Cytotoxins for Drug ConjugatesCytotoxins are very effective at killing cancer cells and have been used in the development of several FDA-approved ...
The principle is that these particles have high linear energy transfer (LET), meaning they can transfer their energy to target tissues or cells in a short period, causing significant cell damage. Therefore, therapeutic RDCs can be used to kill cancer cells or alleviate pain in cancer bone metastasis treatment. ...
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. ...
This refers to a cryomicroneedle shorter than 1 mm, which is loaded and stored with living mammalian cells in vivo and delivers therapeutic cells into the skin layer. When administering the drug, the patch-shaped device loaded with cryomicroneedle arrays is placed on the skin, and the cryomicroneedles penetrate into the skin, detach from the base ...
Hydrogels have been widely studied as cell scaffolds and drug delivery vehicles because their chemical and physical properties are very close to the natural environment of cells. Hydrogels can encapsulate both cells and biomolecules, and many gel systems can closely control the release properties through systematic changes in the physical and ...
Many cell and gene therapy solutions have shown considerable promise as a source of possible treatments for a wide range of chronic disorders. However, these sophisticated therapies introduce additional barriers such as the requirements for ultra-low and cryogenic storage, which affect numerous steps of the biomedical solutions’ life cycles, from their development to their administration. ...
Keywords Tissue engineering, Islet transplantation, Type 1 diabetes, Vascular graft, Cell-based therapeutics Introduction Type 1 diabetes results from the autoimmune destruction of pancreatic islets and is a growing and chronic health problem throughout the world.1,2 Monitoring of blood sugar levels, and recurrent intervention with exogenous insulin, allow ...
Over time, genetic research have recognized a number of genetic danger variants related to neurodegenerative problems and helped reveal new organic pathways and genes of curiosity. Nevertheless, genetic danger variants generally reside in non-coding areas and should regulate distant genes reasonably than the closest gene, in addition to a gene’s interplay companions in organic networks. ...
In the study, the clinically approved anti-tumor drug doxorubicin was selected as the validation object, which confirmed that the "exosome nanoperforator" could efficiently load it into the exosome, and the drug-loaded exosome could transport doxorubicin into lung cancer cells and tumor spheres, induce cancer cell death and inhibit tumor sphere growth. ...
They can be used as stand-alone treatments or can be used as starting materials required for further processing of cell and gene therapeutics. When used as starting materials, they have been shown to have a significant impact on the cost of final cell and gene therapy products. ...
In Type 1 diabetes, insulin-producing cells (known as “beta cells” – hence the name Betalin) in the pancreas don’t function properly. ...
One major challenge for implementing stem cell treatment in the clinics, is the interdisciplinary work required by stem cell biologists and medical doctors as well as the state-of-the-art equipment needed at public hospitals to successfully translate the basic stem cell knowledge into clinical products. Our facility directly serves to speed up ...
ByBaker
Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. ...