Tissue Cells Articles & Analysis: Older
99 articles found
These vectors are uniquely appealing due to their non-pathogenic nature, ability to transduce both dividing and non-dividing cells, and the capacity to induce long-lasting expression of the therapeutic gene. ...
Cell culture is one of the major technologies in the life sciences. It is a general term used to remove cells, tissues or organs from animals or plants and place them in an artificial environment conducive to their survival and/or proliferation. ...
Human brain has approximately 171 billion cells, of which slightly more than half (approximately 86 billion) are nerve cells. These 86 billion nerve cells are a diverse cell population with hundreds of specialized types and functions, but all originate from three neural cell lineages--neurons, oligodendrocytes ...
Collagen is a crucial structural protein, widely presenting in human skin, bones, tendons, ligaments, and other tissues. It's essential for maintaining the structural integrity and function of tissues. ...
In terms of targeted drug delivery, peptidomimetics can achieve target specific cells or tissues in the body. When peptidomimetics are conjugated with targeted antibodies or ligands, they can deliver drugs by selectively getting into diseased cells while reducing off-target effects. ...
Moreover, they can serve as disease biomarkers or drug targets.Studying differentially expressed proteins is a core area of proteomics, providing us with valuable information about the function and state of cells and tissues under different conditions.Differentially Expressed ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...
Firstly, the protein sample is incubated with a specific antibody, then the antibody-antigen complex is enriched with protein A/G magnetic beads, and finally, the level of protein ubiquitination is detected by immunoblotting.ImmunofluorescenceImmunofluorescence is a method for detecting the distribution and location of proteins in cells or tissues and can also be ...
Here are the typical steps for protein ubiquitination IP.Analysis Workflow1. Extraction of Cells or TissueCollect cell or tissue samples and lyse the samples with an appropriate cell lysis buffer (containing protease inhibitors) to release proteins.2. Sample Pre-TreatmentSamples can be broken down by sonication or centrifugation ...
After the bait protein reacts with the target protein, a band corresponding to the target protein can be detected depending on the bait protein used.Experimental Materials1. Samples: Cell or Tissue Extracts2. Western Blot Kit With Ubiquitination-Specific Antibody and Target Protein-Specific Antibody3. ...
In contrast, monoclonal antibodies have higher specificity because they target only a single epitope and isotype, making them perform well in research on natural tissues, such as IP and flow cytometry applications.Literature SearchOnce the required antigen and antibody characteristics are determined, the next step is to conduct an in-depth literature search to find publicly ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of post-translational ...
Nanobodies can be engineered to specifically target tissues or cells of interest by conjugating them to therapeutic agents. ...
This mechanism is often referred to as a "space-saving" or "economical" process because it allows cells to achieve greater protein diversity using a relatively limited number of genes. ...
Dendrimers can also be designed with targeting ligands that allow them to selectively deliver drugs or imaging agents to specific cells or tissues, perfecting their effectiveness and reducing off-target effects. ...
Nanoparticles can be engineered to target specific cells or tissues, such as cancer cells, minimizing the impact on healthy cells and reducing side effects. ...
Cellular Sources of MMPs MMPs are produced by a variety of tissues and cells. MMPs are secreted by pro-inflammatory cells and uteroplacental cells, including fibroblasts, osteoblasts, endothelial cells, vascular smooth muscle, macrophages, neutrophils, lymphocytes, and cytotrophoblasts. ...
Together, these components contribute significantly to understanding the stupefying wonders of life down to our very cells If we consider the biological perspective, amino acids serve as the building blocks for proteins. ...
It acts on the surface of the thyroid follicular cells through a specific receptor known as the TSH receptor (TSHR). This interaction triggers a series of intracellular signaling events that ultimately stimulate the production and release of thyroid hormones, mainly thyroxine (T4) and triiodothyronine (T3). ...
By comparing changes in the lipidome and related enzymes in cells or tissues in disease states and normal states, potential target proteins are identified. ...