tissue damage Articles
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Chaperone hsp27, a novel subunit of auf1 protein complexes, functions in au-rich element-mediated mrna decay
Controlled, transient cytokine production by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-localized AU-rich elements (AREs) that associate with RNA-binding proteins. The ARE-binding protein AUF1 forms a complex with cap-dependent translation initiation factors and heat shock proteins to attract the mRNA degradation machinery. We refer to this protein ...
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Evidence of impaired health in yellow perch (Perca flavescens) from a biological mercury hotspot in northeastern North America
Few studies have investigated the effects of Hg on wild fish from remote areas, even though these fish can have high total Hg concentrations. In Kejimkujik National Park and National Historic Site (KNPNHS), Nova Scotia, Canada, concentrations of total Hg in many yellow perch (Perca flavescens) currently exceed the estimated threshold level for adverse effects in fish (0.2 µg Hg g−1 (wet wt), ...
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Pre-Clinical Effectiveness - Case Study
VersaWrap as a Protective Interface Background: Fibrous scar tissue between tendon and the surrounding tissue is a common complication following flexor tendon repair. Several factors contribute to scar tissue formation, including damage to the tendon sheath, suture placement, and tendon immobilization. Scar tissue formation results in increased work of flexion (WOF) and contracture formation, ...
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Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis
Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. Evaluation of potential antifibrotic therapies are limited using conventional non-human animal ...
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PainShield by NanoVibronix is a type of ultrasound therapy for pain that delivers fast pain relief for nerve and soft tissue damage.
Medical research indicates that nearly 93% of children in America suffer at least one middle ear infection, which is severe enough to see a doctor. Most will suffer repeat occurrences, up to a dozen or more in childhood. These painful episodes are difficult for children, parents, and caregivers. Accurate diagnosis of middle ear infections (Otitis Media) in infants and young children may be ...
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Custom fit helmets – can they help protect against concussions?
It appears that high-contact sports such as hockey and football are becoming much more violent. Although both sports have made efforts to remove unnecessary hits from the game, concussions are inevitable when athletes are as strong and fast as they are today. The only reasonable solution is to improve the safety equipment the players use in hopes of protecting them from a traumatic brain ...
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Jerusalem firm in funding bid to test ‘micro-pancreas’ on humans
An implantable ‘micro-pancreas’ with the ability to produce insulin in response to blood glucose levels has been created by Israeli scientists. Betalin Therapeutics has tested the technology on animals with some success and is now looking to raise enough funds to be able to put it through clinical trials. It combines cells and a biological scaffolding, which situates those cells and ...
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Protection of gastrointestinal and haematopoietic systems by ascorbic acid-2-glucoside in mice exposed to whole-body gamma radiation
Whole-body exposure of mice to gamma radiation leads to depletion of tissue antioxidant defence and damages the haematopoietic and gastrointestinal systems in mice. Administration of ascorbic acid-2-glucoside (AsAG) at a dose of 100 mg/kg body weight could prevent the radiation-induced reduction of total White Blood Cell (WBC) count and decrease in bone marrow viability following whole-body ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Application of Enzyme Detection in Clinical Diagnosis
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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A Natural Polysaccharide-based Bioadhesive for Wound Repair Found
Hundreds of millions of people suffer skin tissue damage every year, including accidental injury, surgical injury, chronic ulcer, etc., and severe cases may lead to amputation or even life-threatening. Suturing is currently the preferred method for clinically closing wounds. However, wound suturing takes a long time during the operation, and removing the stitches will cause secondary damage to ...
By CD BioGlyco.
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Science: Blocking fibrin holds promise for the treatment of periodontal disease
In a new study, researchers from the National Institute of Dental Craniofacial Research (NIDCR) have found that blocking the function of a coagulation protein prevents bone loss caused by periodontal (gingival) disease in mice. According to animal and human data, they found that the accumulation of this clotting protein called fibrin triggers an excessive immune response that damages the gingiva ...
By Matexcel
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Multifunctional Black Bioactive Ceramic Material Developed Recently
Bioceramic materials have a long history of being used to repair human hard tissues, from biologically inert materials (such as alumina and zirconia, etc.) to biological materials that are both biologically active and degradable (such as phosphate and silicate bioceramics, silicon Based bio-glass, etc.), its physiological function is no longer a simple tissue filling substitute, but a tissue ...
By Matexcel
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Suture Knotting Techniques
Sutures are sterile surgical strands or threads used to sew damaged body tissues together after an injury and repair lacerations. Once the sutures are satisfactorily placed, they must be secured with knots, which should be tightened sufficiently to approximate the wound edges without constricting the tissues or impeding blood flow. That said, a completed knot should be firm so that it ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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Beyond Insulin: Immunotherapy for Type 1 Diabetes-PI
Type 1 diabetes (T1D) is a complex T-cell-mediated autoimmune disease that results in the destruction of insulin-producing beta cells and inadequate insulin secretion. Prior to the discovery of insulin in 1921, patients with T1D died within a year or two of diagnosis. Since the discovery and mass production of insulin, T1D is no longer a terminal disease. However, over time, many patients still ...
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Best Material To Practice Your Suturing Skills
You've probably heard amazing stories of surgeons performing successful, yet extremely delicate and risky procedures such as open-heart surgery, separation of conjoined twins, craniotomy, thoracic aortic dissection repair, oesophagectom, spinal osteomyelitis surgery, and many more. As a medical student, you wonder how a surgeon can do such an incredible job. Well, the answer lies in lots of ...
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Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Abstract Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular recreational tool among adolescents and adults. Although the use of ENDS is often promoted as a safer alternative to conventional cigarettes, few comprehensive studies have assessed the long-term effects of vaporized nicotine and its associated solvents, propylene glycol (PG) and vegetable glycerin ...
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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The Sophisticated Mechanism of Epigenetic Induction Facilitating Cellular Proliferation Service
The intricate nature of cellular growth and proliferation has been a fascinating subject of study for cell biologists for many decades. Recently, with the advent of cutting-edge gene manipulation and control techniques, increasing emphasis has been laid on comprehending the role of epigenetic induction in facilitating cell growth. This article focuses on shedding light on the ingenious process of ...
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