Trace Metals Articles & Analysis
3 articles found
Abstract In pharmaceutical synthesis, heavy metal catalysts are commonly used, and their residues often remain in the final product. These heavy metals—primarily from catalyst residues—not only affect drug efficacy but also pose serious health risks to patients. As a result, pharmacopoeias in various countries impose strict limits on heavy ...
Under high humidity conditions, trace metals present in excipients catalyze its oxidation to form captopril disulfide. However, due to the presence of ionic species that interact with metals and can accelerate the degradation of captopril, mineral water is more conducive to maintaining drug stability than distilled water. ...
They are usually the result of amino acid residues reacting with trace metals (copper or iron) or incomplete protein reduction. Oxidation The side chains of methionine, cysteine, histidine, tryptophan or tyrosine residues are prone to oxidation, with methionine being the most reactive residue. ...