Special Genes May Affect the Level of Lipopolysaccharide in the Body’s Blood
Transfer of lipopolysaccharide from gram-negative bacteria into the systemic circulation of the body leads to the development of endotoxemia, which is detected in cardiometabolic diseases such as cardiovascular disease and obesity in addition to acute infections. Lipopolysaccharide is a virulence factor produced by bacteria, which often triggers systemic inflammation through the body's circulation; recently, in a study published in Journal of the American Heart Association entitled 'Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke,' scientists from the University of Helsinki in Finland discovered a genetic marker associated with elevated lipopolysaccharide levels in the body's blood through research.
Microorganisms are part of the human body, and bacteria or their components often eventually enter the body's blood circulation, one of the bacterial components is lipopolysaccharide (LPS), which is a toxin; high concentrations of lipopolysaccharide in the blood can trigger sepsis; and lower lipopolysaccharide levels (endotoxemia) can trigger low-grade inflammation. In fact, endotoxemia is often associated with the development of obesity, which may predict a higher risk of diabetes and cardiovascular disease.
In the study, the researchers measured lipopolysaccharide levels in the blood of more than 11,000 Finnish people, followed by genome-wide association analysis of participants to map the association between their body lipopolysaccharide levels and the genome, and after further analysis the researchers used the FinnGen cohort, which contains genomic and disease-related data from 200,000 Finnish people. Researcher Jaakko Leskela said that as a brand-new finding, we identified a clear association between the human body's genome and bacterial toxin levels in the blood.
Blood coagulation and defense against infection are two interrelated characteristics, which are actually beneficial to wound healing, that is, it is necessary to block the body from bleeding; it is also necessary to protect the wound from infection; the researchers elucidated the association between endotoxemia and some characteristic genes related to blood coagulation in the article. This study links endotoxemia to thrombosis, stroke, and other diseases associated with blood coagulation.
Therefore, genes beneficial for wound healing may also have an adverse relationship with low-grade inflammation in the body; although researchers do not know how these genes associated with blood coagulation affect endotoxemia in the body, elucidating their association may also be a big step forward. The results of this study suggest that the quality of the human microbiome may have some impact on the body's risk of cardiovascular disease. There is still some way to go for later researchers to study in this area, but it is very clear to researchers that this study may help develop new methods to study and treat low-grade inflammation associated with endotoxemia.
In summary, the results of this study suggest that the biological activity of circulating lipopolysaccharides in the body may have a small but very important genetic component; endotoxemia is directly related to genetic variations in contact activation pathways, vasoactivity, and lipoprotein metabolism, which play a very critical role in host body defense, lipopolysaccharide neutralization, and thrombosis, and then thromboembolism and stroke.
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