Obesity Articles
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Unleashing the Potential of Bacterial Genome Editing: A Gateway to the Future
Technological advancements and innovative research have continuously led to the discovery and development of new methodologies in the field of biological and medical sciences. One such breakthrough discovery is bacterial genome editing, which opens a new world of opportunities and challenges in the field of biotechnology and genomics. Understanding Bacterial Genome Editing Bacterial genome ...
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A Closer Look at Metabolic Disease Models and Diabetes Models
Diabetes, specifically Type 1 and Type 2 Diabetes Mellitus, remains one of the most commonly encountered metabolic diseases worldwide. The complexity and diversity of these conditions necessitate the development of detailed medical models for a comprehensive understanding of the diseases. Over time, Type 1 and Type 2 Diabetes Mellitus Models, Metabolic Disease Models, and generalized Diabetes ...
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IPEG 2023: Setting a Foundation for Healthcare Transformation
I recently had the pleasure of attending the IPEG annual meeting in Sorrento, Italy. The collegiality of the surgeons attending the conference was fantastic, and the views of Sorrento and the Island of Capri were stunning. With smaller accessible markets (due to smaller patient volumes and higher incidence of rare disease), specialty areas like pediatrics have been overlooked and under-addressed ...
By Caresyntax
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Overview of Diabetes: Prevalence Assessment, Treatment And Prevention
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. In China, there are more than 114 million adults with diabetes, accounting for about a quarter of the world's diabetes patients. With the change of living and eating habits, diabetes has become the third major factor affecting human health after ...
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Unravelling the Hypertension Puzzle
In this busy and crowded world, no one has the time or energy to look after themselves; our lack of effort and diminished sense of responsibility towards our health has led to stress, tension, and various health issues becoming an inseparable part of our lifestyle. One of the most popularly spread health issues is hypertension. According to estimates by The World Health ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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Involvement of the inorganic phosphate transporter Pit1 in insulin signaling and metabolism - Case Study
PiT1, initially identified as retrovirus receptor, is a transmembrane protein of the sodium-phosphate co-transporter family. PiT1 also has independent functions of its role as a phosphate transporter, notably on cell proliferation, adhesion or apoptosis. These observations suggest that interactions of PiT1 with other molecular partners may impact not only the homeostasis of inorganic phosphate, ...
By Inovarion
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Diagnosing heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine, overtaking heart failure with reduced ejection fraction (HFrEF) and becoming the most common form of heart failure, with a prevalence that is increasing by 1% annually.[1] Despite this, there remains no gold standard in diagnosing HFpEF. Diagnosing ...
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The Health Effects of Probiotics on the Human Body
Probiotics are a type of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They can produce definite health effects to improve the host's microecological balance and play a beneficial role. In 2001, the World Food and Agriculture Organization (FAO) and the World Health Organization (WHO) also defined probiotics as follows: Live bacteria that can ...
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Project - Sublingual Dual Incretin Inhibitor (GLP-1/GIP)
Biolingus explores the development of a sublingual dual incretin inhibitor. BioLingus will position these products in the “epidemic” markets of obesity and type II diabetes : More than 400 MM people suffer from diabetes today. The global type 2 diabetes market is expected to grow to $58.7 billion by 2025, with an annual growth rate of 6.5%, according to research and consulting ...
By BioLingus AG
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The tiny grabber that plucks blood clots out of a vein (The Mail on Sunday)
Thousands of patients suffering from deep vein thrombosis (DVT) are set to benefit from a lifesaving procedure using a new blood clot grabbing device pioneered by NHS specialists. The treatment involves inserting a stent, a tiny, ball- shaped wire cage into a blocked vein. Once in position, the collapsible cage is expanded and ‘ catches’ the clot. When the device is pulled out, the ...
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Applications of 16S/18S/ITS Amplicon Sequencing
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms. 16S/18S/ITS amplicon sequencing reveals the species of microorganisms in environmental samples and their differences, relative abundance, population structure and ...
By CD Genomics
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Application of Plant Oil in Cosmetics
Plant extract, such as plant oil, is generally believed to inhibit the evaporation of water, rehydrate the dry skin and hardened cuticle, restore the softness and elasticity of the stratum corneum, and make the skin smooth, soft and elastic. It can be used as an emollient. Oils are also cosmetically modified agents that determine the skin status such as spreadability, lubricity, moisture, ...
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How Sleep Deprivation Can Lead to Weight Gain
Sleep is an important factor to help maintain health and well-being. It’s recommended that an adult should get at least 7 hours of sleep a night. Getting a good night’s sleep has many benefits such as better memory, reduced stress levels and lowers the risk of heart disease. On the flip side, not getting enough sleep regularly can have serious repercussions such as a weaker immune ...
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Huateng Pharma Develops Intermediates of Semaglutide For TD2
According to the latest IDF Diabetes map, the global prevalence of diabetes reached 10.5% in 2021, with 537 million adults living with diabetes. China has become a disaster zone for diabetes, with the largest number of adults with diabetes in the world. In the past 10 years (2011-2021), the number of people with diabetes in China increased from 90 million to 140 million, an increase of 56%. The ...
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Sacral Insufficiency Fractures in a Geriatric Patient Treatment with the Curvafix IM System - Case Study
CASE PRESENTATION A 70-year-old female had a ground-level fall. Computed tomography imaging showed sacral insufficiency fractures in the left ala. No lumbar fracture was observed. Conservative treatment was initiated but the patient was referred 6 weeks post injury, unable to mobilize with a walker and needing a wheelchair. There was no anterior pelvic pain with palpation or weight bearing, but ...
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Association between Diabetes Mellitus and chronic kidney disease with Muscle loss and weight loss
Muscle loss / muscle wasting is the condition in which, proteolytic systems for protein degradation are activated, while protein synthesis decreases, thereby resulting in muscle fiber shrinkage. This condition may be due age or might be due some chronic conditions like Diabetes mellitus (DM) or chronic kidney disease (CKD). Extreme muscle wasting often results in weight loss. Such a condition is ...
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Pressure Ulcer - Case study
Patient History Patient presented with a history of hypertension, hyperlipidemia, peripheral arterial disease, obesity, arterial fibrillation, and transient ischemic attack. Patient had total knee replacement surgery and developed a complication due to improper off-loading, developing pressure ulcer on the right heel. Patient was treated with collagen products and wet to dry dressings prior to ...
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Introduction to Lipogenesis, Lipid Anabolism and Catabolism
Sources of Fat Fat, also known as triglyceride, is made by condensing one molecule of glycerol and three fatty acids. The source of fatty acids in the body: one is the body's own synthesis, and the other is the food supply. Some unsaturated fatty acids cannot be synthesized by the body and depend on food supply, called essential fatty acids. There are mainly two kinds, one is the ω-3 series ...
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