Alcyomics Ltd. products

Skimune®Chem is a non-animal human in vitro skin explant assay used as a safety assessment tool for testing chemicals and household products. The assay determines if the test chemical has the potential to provoke an adverse immune response and react with the skin causing histopathalogical damage, symptomatic of skin allergy and skin sensitisation. The assay can distinguish between sensitising and non-sensitising chemicals, predicting which chemicals would cause skin sensitisation in vivo. (Ahmed, S.S, Wang, X.N, Fielding, M, Kerry, A, Dickinson, I, Munuswamy, R, Kimber, I, Dickinson, A. M. An in vitro human skin test for assessing sensitization potential. J Applied Tox (2016) 36:669684.

Alcyomics Skimune®Mab was developed to determine efficacy, potency, dose responses and detection of adverse immune responses to biologics, i.e. monoclonal antibodies (including their aggregated format), biosimilars and aptamers. It can be used as a valuable tool for pre-clinical testing by bridging the gap between animal testing and first-in-man studies; it facilitates the product profile to support clinical trials.

Our human tissue explant assay for the detection and characterisation of adverse immune reactions in vitro. Helping you characterise immune reactions to your novel chemicals, pharmaceuticals, biologicals and cellular therapies.

Assessment of immune activation: Alcyomics has a wide range of cell phenotypic services for your research needs, to benefit both drug discovery and validation. With our in-house state-of-the-art instrumentation, we can analyse and deliver accurate analyses of T-cell proliferation responses and perform multiplex cytokine analysis. This screening test can be used in conjunction with the Skimune® assay to determine adverse immune or allergic reactions to drugs and compounds in both the autologous and allogenic immune settings.

Disease specific in vitro models for your research. Skimune AD: Our advanced Skimune® model stimulated to demonstrate an AD phenotype through addition of inflammatory cytokines and autologous immune cells.