AnaBios Corporation products

Functional Human Spinal Cord Tissue & Cells: AnaBios recovers human spinal cord tissue and cells in a highly viable state in order to probe the effects of compounds on spinal cord neurons. We have developed highly specialized recovery techniques to maintain tissue and cell viability such that the tissues can be sliced by vibratome and maintained in culture for weeks (organotypic culture). Researchers interested in the transcriptomic or proteomic signature of human spinal cord can acquire flash frozen or fixed human spinal cord samples at specified vertebrate levels with confidence that the tissue quality remains at the same level as human spinal cord used for organotypic culture.

AnaBios primary human hepatocytes are isolated from donated human livers. All donated human organs and tissue have been ethically consented for research. Primary human cryopreserved hepatocytes are ideal for many scientific applications, including toxicity, metabolism, disease modeling, genomics, enzyme-mediated mechanisms, uptake, intrinsic clearance and more. When plated, human hepatocytes from the liver are metabolically active for 5-7 days and ideal for more extended studies, including transporter, induction and toxicity. Suspension format hepatocyte cells are suitable for shorter-term analysis between 2-4 hours, including clearance and metabolism studies.

A human dorsal root ganglion (DRG) is the cluster of neuronal cell bodies that bilaterally lay along the spinal cord and form a principal element of the peripheral sensory neural system. Sensory stimuli are relayed via nerve fibers to the dorsal root ganglion and are transmitted to the spinal cord through synaptic connections to spinal cord neurons within the dorsal horn. Molecular discovery with human DRG is providing pain investigators with potential new targets for addressing pain and important evidence about peripheral nerve structure. Using customized techniques, AnaBios recovers human dorsal root ganglia in a highly viable state in order to probe the electrophysiological properties of the DRG neurons and assess compound effects on DRG neuronal excitability. Therapeutic compounds can be assessed for their analgesic potential by testing them on human dorsal root ganglia neurons.

Human Lung Tissue for Translational Research. The human lung is a key organ for multiple therapeutic endpoints, as well as a system that must be evaluated for potential drug-induced toxicities to ensure safety. Modeling the complex interplay of respiratory and vascular components through a reductionist approach has proven to be exceedingly difficult as significant differences exist between preclinical animals and humans1.  To that end, AnaBios offers cryopreserved human precision-cut lung slices (PCLS) as an ex vivo preparation that maintains the complex cellular composition, native architecture and functionality of human lung tissue2.

AnaBios offers high quality human brain and other neurological tissue samples recovered via our propriety methods. Tissue recovery may be customized to meet your specific experimental needs. AnaBios offers normal and diseased human tissue samples. In addition, we provide demographic details, including sex, age, ethnicity, BMI and cause of death.