AnaBios - Human Dorsal Root Ganglia Tissue
From Human Tissue & Cells
A human dorsal root ganglion (DRG) is the cluster of neuronal cell bodies that bilaterally lay along the spinal cord and form a principal element of the peripheral sensory neural system. Sensory stimuli are relayed via nerve fibers to the dorsal root ganglion and are transmitted to the spinal cord through synaptic connections to spinal cord neurons within the dorsal horn. Molecular discovery with human DRG is providing pain investigators with potential new targets for addressing pain and important evidence about peripheral nerve structure. Using customized techniques, AnaBios recovers human dorsal root ganglia in a highly viable state in order to probe the electrophysiological properties of the DRG neurons and assess compound effects on DRG neuronal excitability. Therapeutic compounds can be assessed for their analgesic potential by testing them on human dorsal root ganglia neurons.
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Servcies Overview
This approach differs from traditional biobanks which recover human tissue to assess human pathology but do not maintain the tissue in good electrophysiological condition. In addition to dorsal root ganglia from healthy donors, AnaBios has access to human DRG from human donors with chronic pain and other neuropathic conditions.
This access enables researchers to characterize the molecular changes associated with inflammatory and neuropathic pain, and to assess whether compounds have enhanced or reduced effect on chronic pain tissue.
Researchers interested in the transcriptomic or proteomic signature of human dorsal root ganglia can acquire flash frozen or fixed human DRG at specified vertebrate levels with confidence that the tissue quality remains at the same level as human DRG used for electrophysiology.
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