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Agelenin has been isolated from the venom of the Agelenidae spider Agelena opulenta. This toxin suppresses the excitatory postsynaptic potentials possibly by blocking the presynaptic calcium channel.

Alpha-conotoxin GI act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This conotoxin has been isolated from the venom of the cone snail Conus geographus. The higher affinity site for alpha-conotoxin GI is the alpha/delta site on mouse muscle-deriverd BC3H-1 receptor, and the other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ.