- Home
- Companies
- Eliaz Therapeutics
- Articles
Eliaz Therapeutics articles
‍Annotations
- Serum Gal-3 concentration increased in patients with septic shock and mice undergoing sepsis induced by a procedure called cecal ligation and puncture (CLP).
- Mice genetically deficient in Gal-3 (Gal-3 KO) were more resistant to sepsis caused by CLP than wild-type mice (WT).
- Gal-3 KO mice show an increased number of neutrophils in the initial stage of infection and reduced bacterial loads in the peritoneal cavity and blood.</
Annotations
- Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury
- Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects.
- MCP- treated mice demonstrated increased renal function and reduced renal fibrosis after cisplatin- induced MCP-treated mice showed decreased renal fibrosis and apop
Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI.
Methods: Among fifty-two post-cardiac surgery patients, serum and urine Gal-3 levels were examined on intensive care unit (ICU) admission. In a rat renal I/R injury model, Gal-3 levels, renal
Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3`s role and its potential utility as a therapeutic target in S-AKI.
Methods: In 57 patients admitted to the intensive care unit (ICU) with sepsis, serum Gal-3 was examined as
Annotations
- Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve.
- Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the lowest third.
- Elevated preoperative Gal-3 levels significantly improve predictive ability over existing clinical mod