7 Articles found
Eliaz Therapeutics Articles
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Galectin 3 Inhibition Attenuates Renal Injury Progression in Cisplatin-Induced Nephrotoxicity
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the ...
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A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. Methods: ...
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AU2012348311 - Reduction of galectin-3 levels by plasmapheresis
Abstract The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on ...
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Galectin-3 in septic acute kidney injury: a translational study
Abstract Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore ...
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Cardiovascular Consequences of Acute Kidney Injury
Annotations Acute kidney injury (AKI) is recognized as a potential risk factor for future cardiovascular events, especially heart failure. Up to 60% of patients with severe AKI who are admitted to an intensive care unit (ICU) die; the long-term ...
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Elevated Preoperative Galectin-3 Is Associated With Acute Kidney Injury After Cardiac Surgery
Annotations Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve. Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < ...
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Galectin-3 Aggravates Experimental Polymicrobial Sepsis by Impairing Neutrophil Recruitment to the Infectious Focus
Annotations Serum Gal-3 concentration increased in patients with septic shock and mice undergoing sepsis induced by a procedure called cecal ligation and puncture (CLP). Mice genetically deficient in Gal-3 (Gal-3 KO) were more resistant to ...