H & D S.r.l. applications

REDOX OB FAST enables the assessment of oxidative stress status through redox balance analysis. In every organism there is a delicate balance, called redox, between oxidising and antioxidising molecules. It is well known in the literature (Nat Rev Mol Cell Biol. 2020, 21:363-383.) that alterations in the redox balance, i.e. oxidative stress, are associated with numerous diseases, especially chronic or age-related diseases (diabetes, cardiovascular diseases, neurodegenerative diseases, …. ). In this context, it is therefore necessary to have analytical tools capable of assessing the redox status of an individual. Recently, it has emerged that an ideal analytical tool is one that can assess the systemic redox profile by analysing a capillary blood sample (Antioxid Redox Signal. 2020, doi: 10.1089/ars.2020.8212.).

The d-ROMs FAST Test allows the blood concentration of peroxides to be determined. Peroxides are a recognised marker of oxidative stress derived mainly from lipid oxidation (Cur Med Chem. 2005, 12:1161-1208.). Some classical molecules used as markers, such as MDA or isoprostranes, only identify the damage that has occurred, as they are the last products of oxidative processes. Peroxides, on the other hand, are the first products of oxidative processes, and among other things retain a certain pro-oxidant power themselves, so their quantification enables an early determination of the onset of oxidative stress, ensuring the possibility of early intervention.

The PAT test allows the antioxidant power of the blood to be determined. As the antioxidant power of the blood is the first defence against the development of an oxidative stress condition, it is particularly useful to determine this.

The SAT test is used to determine the antioxidant power of saliva. As the antioxidant power of saliva is the first defence against the development of an oxidative stress condition, its determination is particularly useful. A substance with antioxidant capacity is defined chemically as a molecule with reducing properties. Reducing properties are not an absolute but a relative characteristic, so the choice of reference molecule becomes important.