8 products found
Ncardia Services B.V. Products
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Modeling - Established Cell Models - Human iPSC in Vitro Models - Cardiac
Proven, relevant iPSC-derived cell models from Ncardia. Physiologically relevant and fully functional cell models manufactured to-scale and available in a constant supply. Streamlined, de-risked process development. We specialize in building processes from laboratory protocols into differentiation procedures that are robust and ready to scale. This includes reducing handling steps and implementing de-risking strategies for your desired iPSC line, that save you time and resources.
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Ncardia - Human iPSC-Derived Atrial-Like Cardiomyocytes
Human-induced pluripotent stem cell (iPSC) derived atrial cardiomyocytes are a powerful tool to improve in vitro testing of new treatments for atrial arrhythmias. Our team can manufacture atrial cardiomyocytes at the scale needed from the iPSC that best fits your project, ensuring high purity and consistency between batches. Custom assays can be developed based on this model to support your large screenings with minimal ...
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Ncardia - Human iPSC-Derived Vascular Endothelial Cells
Vascular endothelial cells are involved in multiple processess including blood flow, vascular permeability or angiogenesis. Our team can manufacture endothelial cells from the iPSC line that best fits your project with a controlled and scalable process. Custom assays can be developed with this fully functional cell model to screen drug-induced effects on endothelial barrier permeability or 3D capillary tube ...
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Ncardia - Human iPSC-Derived Vascular Smooth Muscle Cells
Alterations in the functionality of vascular smooth muscle cells are associated with the progression of pathological conditions such as inflammation, atherosclersosis or pulmonary hypertension. Our team manufactures, at scale, vascular smooth muscle cells derived from the iPSC line that best fits your project. This in vitro ...
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Modeling - Established Cell Models - Human iPSC in Vitro Models - Neural
Our scientific team has established standard procedures for the differentiation of iPSC lines into multiple cell types in the cardiovascular and neurological lineages that can be supplied at scale large enough for modeling, assay development and screening.
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Ncardia - Human iPSC-Derived Astrocytes
Astrocytes are essential players in neurodegenerative disease progression providing a valuable tool for drug discovery and disease modeling. Human iPSC-derived astrocytes generated with our standardized process express key identity markers and support co-culture with human iPSC-derived neurons. Our team can manufacture astrocytes at scale ...
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Ncardia - Human iPSC-Derived Cortical Neurons
Cortical neurons play a vital role in many neurodegenerative diseases, including Alzheimer’s disease. Human iPSC-derived cortical neurons can be co-cultured with astrocytes and microglia to model neurodegenerative diseases. Our team can manufacture cortical neurons at scale from the iPSC line that best fits your project or work with off-the-shelf Ncyte Cortical Neurons to support your drug discovery ...
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Screening - Efficacy
Our scientific team is highly experienced in developing and optimizing a wide range of custom assays for efficacy evaluation at high-throughput based on the most clinically relevant readouts for your project.
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Ncardia - Angiogenesis
Angiogenesis, the sprouting of new blood vessels from pre-existing vasculature, plays an important role in the maintenance of body homeostasis and the progression of cancer and Alzheimer’s disease, among others. Studying vessel formation can help identify and validate targets and candidates for treatment of a variety of diseases. Using Ncardia’s human iPSC-derived ...
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Calcium Transients
Disturbances in calcium signaling are associated with many neurodegenerative diseases and cardiomyopathies. Fluorescence-based assays with iPSC-derived cardiac and neuronal models can be used to monitor short and long-term drug-induced changes on calcium transients. Our scientists develop the most optimal calcium transient assay for each project and can scale it up for high-throughput screening, to accurately evaluate efficacy and safety of drug ...
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Technology
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iPSC Technology
The discovery that transformed biological research. In 2007, Shinya Yamanaka and Kazutoshi Takahashi were able to reprogram human somatic cells into pluripotent stem cells by inducing the expression of four embryonic transcription factors. The resultant cells were called human induced pluripotent stem cells (iPSC). iPSCs have unlimited proliferation capacity and can be differentiated into nearly any cell type in the body. These characteristics rapidly ...