Neurodigitech, LLC products

This Kit I is designed for the detection of degenerating neurons in fixed tissue sections of the central nervous system from experimental animals. The principle of this kit is based on the finding that some components of the neurons undergoing degeneration, such as lysosomes, axons, and terminals, become particularly argyrophilic. Under certain conditions, these cellular elements bind to the silver ions with high affinity. Upon reduction, the silver ions from metallic grains are visible under a light or electron microscope. NDT103 Kit has been widely used in animal studies under various experimental conditions1-16. This kit has proven extremely specific and sensitive for the detection of degenerating neuronal somata, axons, and terminals in both the brain and the spinal cord (see photo below).  It is particularly useful for the detection of small numbers of degenerating neurons that may not be demonstrable with routine histopathological techniques.