More than $1 billion in contract value awarded by the U.S. government
SIGA’s most recent contract with the Biomedical Advanced Research and Development Authority (BARDA), primarily for the maintenance of a strategic stockpile of smallpox antiviral therapy, was awarded in September 2018 and has a value in excess of $600 million (if all options are exercised). To date approximately $240 million of TPOXX® has been delivered under this contract. In 2011, SIGA was awarded a contract with BARDA which led to the delivery of $460 million of oral TPOXX® to the strategic stockpile.

SIGA has worked closely with the U.S. Government during the development of TPOXX® and has cultivated relationships with key health security constituencies in the U.S. government, including the Biodefense Advanced Research Development Authority (BARDA), the National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), the Defense Threat Reduction Agency (DTRA), U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), and the Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRN). These relationships have generated consistent, long-term mutual benefits that have helped to advance the development of TPOXX® while enhancing U.S. national health security and preparedness against a potential smallpox threat.

Proven drug development capability including development under the Animal Rule
SIGA has established an end-to-end network with over 20 partners across discovery, pre-clinical, clinical, manufacturing and supply chain that supported development of TPOXX® and successful delivery of approximately $200 million of courses to the Strategic National Stockpile. In addition, development and approval of TPOXX®, the first drug approved to treat a disease that no longer exists in the human population, required a unique regulatory approach based on the FDA’s Animal Rule. We have developed a robust drug development capability supported through U.S government investment in Biodefense, and our highly externalized cost structure minimizes fixed costs and provides scalability. SIGA intends to leverage the unparalleled expertise, infrastructure, and relationships amassed in support of the TPOXX® program in additional health security opportunities.

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