SYnAbs S.A. products

Custom Monoclonal Antibody Development

Transmembrane Proteins Effector Monoclonal Antibodies

Transmembrane proteins are probably the most complex and challenging antigens to target with monoclonal antibodies. Indeed, despite their strong presence in the animal kingdom and their implications in many cellular mechanisms, they remain very difficult to access due to intrinsic properties.

Epigenetic Antibodies

The histone H3 of certain tumors is methylated at the level of a lysine in an area which is highly conserved and identical in humans and mice. Volition company initially worked with a polyclonal but with the specificity problems that this entails. After several unsuccessful attempts to obtain a monoclonal antibody directed against this methylated lysine in mice and rabbits, Volition then entrusted this work to Synabs to try to obtain a monoclonal in rat species. Final obtained rat mAbs make the difference between methylated and non-methylated lysine on histone DNA. An immuno-assay has been consequently developed under NuQ brand and is now marketed.

Carbohydrate Antibodies

Polysaccharides and carbohydrates can be classified on the basis of their monomer composition. It is so usual to distinguish between homo and hetero polysaccharides, depending on whether they have one or more monosaccharide units. Glucans are polymers of D-glucose (a.k.a. dextrans), galactans are polymers of D-galactose and xylans of D-xylose polymers. Chitosans are polymers of D-glucosamine.

Primary Monoclonal Antibodies

Therapeutic Blocking Anaphylatoxin Receptor - Antibodies

hC3aR expression on the immunocompetent rat cell line. In black: non transfected rat cell line with a mean fluorescence of 4400. In red: stably transfected rat cell line with a mean fluorescence of 563000. Labelling: anti hC3ar Biolegend + GAM AF488.

Therapeutic Treg Depleting Chemokine Receptor - Antibodies

hCCR8 expression on HuT-78 cell line: In black : GAM AF488. Mean Fluorescence 3300. In red: mAb Biolegend + GAM AF488. Mean Fluorescence 13700. In blue: SynCCR8 + GAM AF488. Mean Fluorescence 48300.