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Following the American College of Rheumatology (ACR), the presence of anti-dsDNA antibodies is one of the diagnostic criteria for Systemic Lupus Erythematosus (SLE). Indeed, they are reported to have a high pathogenic and diagnostic significance for SLE. They are among the most frequently detected autoantibodies associated with SLE. Moreover the dsDNA antibody titer usually correlates with ...
The anti-SSA antibodies are directed against SSA (Ro), a protein of 60 kD which belongs to small cytoplasmic ribonucloprotein complexes, the hY-RNP complexes also known as Ro/SSA hY-RNA. These autoantibodies are diagnostic markers and classification criteria for Sjögren’s Syndrome. They are also associated with SLE and Subacute Cutaneous Lupus Erythematosus (SCLE) and present in 90 % ...
Autoantibodies directed to negatively charged phospholipids, in particular cardiolipin, have been detected in the serum of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). APS is characterised by venous and arterial thrombosis, recurrent spontaneous abortions and thrombocytopenia. It is now known that a serum cofactor, β2-glycoprotein 1, is required for ...
ECL 412 is a four channel semi automatic coagulation analyzer. It is compact, ergonomically designed unit packed with many advanced features, whose benefits are readily usable by the end-user. It’s an advanced analyzer for Complete Hemostasis. This four channel coagulation analyzer redefines the benefits in its class. Erba ECL 412, can perform PT, APTT, Fibrinogen, Thrombin Time , All ...
The dsDNA antigen is a 2690 bp plasmid purified by alkaline lysis and chromatography. The purification process includes operations to minimize reactivity to antibodies against single-stranded DNA. Use of plasmid DNA in ELISA is an effective method for the detection of anti-double-stranded (ds) DNA antibodies (1). The presence of antibodies to dsDNA is included in the 1982 revised criteria for ...
Autoantibodies to centromeric proteins in the sera of patients with scleroderma were first described in 1980. Subsequent studies confirmed that anti-centromere antibodies (ACA) were most often found in patients with a limited form of systemic sclerosis previously referred to as CREST syndrome. These autoantibodies are also often detected in sera from patients with Raynaud’s phenomenon and ...
B-cell activating factor (BAFF), is a TNF superfamily member (TNSF13B) best known for its role in the survival and maturation of B cells. BAFF is produced by several cell types and tissues including monocytes, macrophages, neutrophils, dendritic cells, T lymphocytes, spleen, lymph node, and bone marrow. BAFF plays a role in autoimmune disease disorders and is elevated in the serum of patients ...
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