Molecular Diagnostics Articles
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Protein Fusion Extends Drug Half-Life Technology
Protein fusion is a genetic recombination technique in which the DNA of an inactive peptide or protein chain segment to be grafted is recombined with the DNA of a drug and expressed together by engineered cells; no specialized grafting operations are required. In the current technology, the inactive peptide or protein chain segment used for protein fusion is the FC region of albumin and antibody. ...
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Karyotype Analysis for Rare Disease
Karyotype analysis refers to the pairing and grouping of chromosomes to reveal whether the organism accords with the inherent chromosomal characteristics, to determine if the organism has chromosomal abnormalities. Karyotype analysis can detect whether there are abnormalities in chromatin length, centromere position, the ratio of long and short arms, and the presence or absence of satellites. ...
By Protheragen
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Unleashing the Potential of Bacterial Genome Editing: A Gateway to the Future
Technological advancements and innovative research have continuously led to the discovery and development of new methodologies in the field of biological and medical sciences. One such breakthrough discovery is bacterial genome editing, which opens a new world of opportunities and challenges in the field of biotechnology and genomics. Understanding Bacterial Genome Editing Bacterial genome ...
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Unleashing the Potential of Recombinant Adeno-Associated Virus (rAAV) Particles in Gene Therapy
Recombinase Adeno-Associated Virus (rAAV) particles have taken the center-stage in gene therapy research and development due to their exceptional genetic manipulation capabilities, safety and unprecedented therapeutic success. As biomedical science advances, there is an ever-increasing enthusiasm in the usage of rAAV particles as effective vehicles for gene delivery and the subsequent therapy. ...
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Microscale Thermophoresis: Unlocking the Potential of Molecular Interactions
Introduction In the world of molecular interactions, understanding the forces that drive binding events is crucial for advancing scientific research and developing new therapies. One powerful technique that has revolutionized the study of molecular interactions is Microscale Thermophoresis (MST). In this blog post, we will delve into the world of microscale thermophoresis, exploring its ...
By Profacgen
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New Technology to Promote Drug Development-AI Technology
For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput ...
By BOC Sciences
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Nanobodies Definition, Structure, Advantages and Applications
What is a Nanobody?Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages. The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in ...
By BOC Sciences
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Homologous Recombination-mediated Genome Editing Service
As a global leader in recombination-mediated genome editing service, Creative Biogene is dedicated to provide a number of services to achieve scientific results faster than ever before. We have a team of passionate and talented scientists who have years of experience and would work closely with you to provide help in reducing your workload while raising the visibility of your research. In ...
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Overview of Microbial Epigenetics
Introduction to Microbial Epigenetics Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA sequence. Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the ...
By CD Genomics
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Protein Engineering: Designing Molecular Machines for a Healthier Future
Proteins are the workhorses of life, performing a vast array of essential functions, from catalyzing biochemical reactions to building and maintaining cellular structures. Protein engineering, a rapidly evolving field at the intersection of biology, chemistry, and computer science, aims to harness the power of these molecular machines by designing and manipulating their structure and function to ...
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The Importance of Bioproduction Stable Cell Line Development
Bioproduction is a critical element in the creation of many vaccines, therapeutics, and other biopharmaceuticals. A central facet of this process involves the development of stable cell lines that are capable of producing these vital products in abundance and with consistency. This article will explore the in-depth process and importance of stable cell line development in bioproduction. The ...
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Clonality Analysis Service: A Paradigm Shift in Disease Diagnosis and Treatment
Understanding Clonality Analysis Clonality refers to the origin of a cell population from a single 'parent' or progenitor cell through asexual reproduction or division. This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus essential in understanding the evolution and the spread of cancerous cells in a ...
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Biotin PEG
What are Biotinylation and Biotinylated PEG?Biotinylation is the process of covalently attaching biotin to molecules (such as amino acids, peptides, antibodies, or proteins). Due to the small molecular weight of biotin, biotinylation is usually rapid and specific and is unlikely to interfere with the inherent function of the molecule. Biotin has extremely high affinity, rapidity and high ...
By BOC Sciences
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Harnessing the Potential of Marine Polysaccharides as Valuable Resources
Source of Marine Polysaccharides Marine polysaccharides are primarily sourced from a diverse range of marine organisms that thrive in oceans and seas. Seaweeds are the primary and most abundant source of marine polysaccharides. Seaweeds with high polysaccharide content, such as red algae (Rhodophyta), brown algae (Phaeophyceae), and green algae (Chlorophyta), have been extensively studied for ...
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Understanding Residual DNA Testing and Methods for Detecting Residual DNA
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks. Although recombinant protein drugs, antibody ...
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Peptide Vaccine Design
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases. Traditional vaccines rely on the use of inactivated pathogens to trigger an immune response. However, many of these formulations carry a high risk of causing allergies or autoimmune reactions. ...
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Comprehensive Insights into Native Porcine Pancreatin: A Versatile Enzyme Preparation
Native Porcine Pancreatin, an enzymatic mixture derived from the porcine pancreas, has emerged as a fundamental component in various industries due to its unique enzymatic composition. Comprising amylase, lipase, and protease enzymes, this preparation is celebrated for its multifaceted applications and plays an indispensable role in the pharmaceutical, food, and biotechnology sectors. In this ...
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Exploring the Magic of Tn5 Transposase
In the realm of molecular biology and genetic engineering, Tn5 Transposase is a powerful tool that has revolutionized the way we manipulate and study DNA. It's like molecular scissors and glue combined, allowing us to precisely cut, move, and insert DNA sequences. In this article, we will unravel the wonders of Tn5 Transposase, its applications, and why it's an indispensable asset for researchers ...
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Chimeric RNA and Sequencing Technologies: Advancing Detection and Research
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse ...
By CD Genomics
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Epitranscriptomic Modifications and How to Detect Them
What is epitranscriptomic modification? RNA modifications, not limited to purine or pyrimidine bases, including N6-methyladenosine (m6A), 1-methyladenosine (m1A), 5-methylcytidine (m5C), 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (f5C), 5-carboxycytidine (ca5C), inosine (I), pseudouridine (Ψ), and 2′-O-methylation (Nm). RNA modifications can structurally alter the pairing of ...
By CD Genomics
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