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Drug Metabolism Articles & Analysis: Older
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Chronic Obstructive Pulmonary Disease (COPD) is a global health burden characterized by persistent airflow limitation and progressive lung damage. Despite extensive research, translating findings from bench to bedside remains a challenge. Precision Cut Lung Slices (PCLS) have emerged as a versatile tool in COPD research, offering unique advantages for understanding disease mechanisms and ...
Focus on Pharmacokinetics and Toxicology Understanding a drug's absorption, distribution, metabolism, and excretion (ADME) in animal bodies is crucial for determining appropriate dosages and minimizing adverse effects. CD Formulation's pharmacokinetic services provide detailed analyses of these processes, catering to the distinct metabolic ...
First, the team would conduct extensive preclinical investigations to ascertain the safety and effectiveness of the oral thin films. Factors like drug release kinetics, absorption, metabolism, and possible toxicity during the preclinical stage would be assessed. Next, the absorption, distribution, metabolism and excretion of oral film ...
This enzyme plays a fundamental role in various biological processes including gene expression, protein function, and metabolic activity. Thus, having a quality and reliable source of SAHH is vital for research institutions and industries to advance their understanding and application of this pivotal enzyme. ...
Araris Biotech AG, a company pioneering antibody-drug conjugate (ADC)-linker technology, announced today that it has recruited Dr. ...
Tumor drug resistance has long been a key direction of cancer research. Meanwhile, complex factors and multiple mechanisms are known to induce drug resistance occurrence or reoccurrence, covering tumor heterogeneity, DNA damage repair, apoptosis inhibition, epithelial-mesenchymal transition, increased drug excretion or reduced absorption, ...
In the paper, ‘Predicting Regioselectivity of AO, CYP, FMO and UGT Metabolism Using Quantum Mechanical Simulations and Machine Learning’, the team combined existing experimental results, quantum mechanics and machine learning to build predictive models for drug metabolism. [1] The research will underpin the development of new ...
Today it announces to add pharmaceutical and drug standards to its already rich offering of chromatography standards. ...
Maureen Bunger, Senior Product Manager, ADME-Tox Solutions, Lonza Cell and Gene, commented: “Today’s drug discovery success is hugely dependent on performing experiments using the right biological model to best reflect in vivo environments. ...
The in silico platform reduces the cost and timeframe of drug development by reducing the need for iterative pre-clinical experiments and better directing clinical trials, while increasing the effectiveness of the therapeutics themselves. ...
“If any clinician is going to provide precision medicine, they’ll need to know the ability of the liver and kidneys to metabolize and eliminate drugs,” he emphasizes. More than 110,000 people are estimated to die each year from adverse drug reactions, which is when the correct drug is given in an appropriate ...
'According to the study the glutathione S-transferases act to inactivate chemicals so people without these GSTM1 and GSTT1 genes are less able to metabolize environmental chemicals,” said Lourdes Salvador, Founder and President of MCS America. “If a person cannot metabolize chemicals they build up in the body and cause disturbances in normal body function,” added ...