Opioid Drug Articles & Analysis
9 news found
Endogenous peptides with analgesic potential include endorphins via the mu receptor, dynorphins via the kappa receptor and enkephalins via the delta receptor. Kappa and delta opioid agonists have been shown to provide analgesic benefit while sparing toxic mu agonist toxicity1 . Preclinical data supports analgesia from enkephalin without significant opioid ...
A new study published in Proceedings of the National Academy of Sciences (PNAS) indicates, “Delta opioid receptors have a built-in mechanism for pain relief and can be precisely targeted with drug-delivering nanoparticles, making them a promising target for treating chronic inammatory pain with fewer side eects.” Researchers used cells from humans and ...
Substance use is an escalating crisis in the United States, with opioid-related drug overdose deaths rising above 100,000 in 2021.1 The standard of care for treating opioid use disorder (OUD) is medication for opioid use disorder (MOUD), including opioid receptor agonists and antagonists. ...
The increasing prevalence of cancer is expected to propel growth of the global neuropathic pain market over the forecasted period. The global opioids drug market is expected to reach US$ 31 billion by 2027, at a CAGR of 2.5% from the forecasted period of 2020-2027. ...
This is why we have taken our novel lead drug candidate into research and development of an important and potentially life altering indication of CIPN. ...
It is the Company’s leading candidate to treat chemotherapy induced peripheral neuropathy (CIPN), a disorder which currently has no FDA approved drugs for treatment. Current off-label prescription of opioids, a leading agitator of overdose deaths and addiction, is the current model of treatment. ...
Adding to the equation is the off-label use of opioids and gabapentinoids for chronic and neuropathic pain as a result of the unmet medical need and no FDA approved non-opioid drug to treat chronic and neuropathic pain, specifically Chemotherapy-induced peripheral neuropathy (CIPN). ...
(NYSE:PFE) and Eli Lilly and Company (NYSE:LLY) today announced the outcome of the U.S. Food and Drug Administration (FDA) Joint Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee on tanezumab. ...
The completed study could lead to a Phase 2 grant and further advances Kannalife’s belief that KLS-13019 could become a viable drug candidate, and an alternative to opioids, as a treatment for patients suffering from CIPN, and chronic pain management. ...