Drug Discovery Downloads
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PSL - MSR™ Microsphere Refiner - Brochure
The MSR™ MicroSphere Refiner is a cGMP piece of equipment that allows drug developers and manufacturers to complete a wide range of aseptic processes with their microspheres at various scales. It is a one-of-its-kind solution has been developed and refined over decades following a Quality-by-Design (QbD) approach, taking into account the characteristics of microspheres and process behaviour. ...
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IVDR: our next Challenge? - Brochure
With the EU In Vitro Diagnostic Medical Devices Regulation (IVDR) becoming applicable in May 2022, the European Bioanalysis Forum, as many others, is looking at the impact of this regulation on (bio)pharmaceutical drug research and development. Already, we observe a growing concern of the industry on potential scope creep of the IVDR into early clinical studies for assets where it is believed the ...
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Vaccine Assays 2024 - Brochure
Immunogenicity assays play a vital role in evaluating the safety and efficacy of vaccines by measuring the immune response induced in vaccinated individuals, and serve as crucial tools in vaccine development, clinical trials, licensure, and post-marketing surveillance. Various methods are employed in vaccine immunogenicity assays, ranging from traditional techniques like LBAs to advanced ...
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CanaQuest Investor Presentation Q4
A Clinical Stage/Life Sciences company focused on the drug discovery and development of next-generation targeted therapeutics within the endocannabinoid system and specific brain receptors. Partnered with world-leading organizations in research, development, manufacturing, and commercialization with expertise in neuroscience, psychiatry, and professional ...
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CanaQuest Overview_Q4 2023
CanaQuest Medical (CANQF), a clinical-stage, life sciences company, is focused on drug discovery and development of next-generation targeted therapeutics within the endocannabinoid system and specific brain receptors. The Company is prioritizing treating neurological conditions such as epilepsy, anxiety, depression, and Post Traumatic Stress Disorder "PTSD," including ...
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Fentanyl (FYL) Detection Kit - Manual
Fentanyl is a synthetic opioid related to the phenylpiperidines. Fentanyl is approximately 100 times more potent than morphine. This agent is highly lipid soluble and rapidly cross the blood-brain barrier. This is reflected in the half-life for equilibration between the plasma and cerebrospinal fluid of approximately 5 minutes for fentanyl. The levels in plasma and cerebrospinal fluid decline ...
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Titan - Model 357 - 3-In-1 Automated Combinatorial Peptide Synthesizer - Brochure
The Titan 357 synthesizer is a powerful tool for drug discovery. It serves as three automated synthesizers in one. As a parallel synthesizer it prepares up to 36 peptides simultaneously. It is also a 550 mL scale-up synthesizer, as well as a split-and-combine synthesizer for preparing combinatorial peptide libraries. It can prepare split-and-combine libraries containing millions of compounds for ...
By AAPPTec, LLC
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Untargeted Metabolomics Strategy VS Targeted Metabolomics Strategy
Targeted and non-targeted metabolomics take part in food identification, disease research, animal model verification, biomarker discovery, disease diagnosis, drug development, drug screening, drug evaluation, clinical research, plant metabolism research, and microbial metabolism research. ...
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Nuclear Magnetic Resonance (NMR) in Biopharmaceutical Analysis
Nuclear magnetic resonance (NMR) plays an irreplaceable role in drug research, development, and manufacturing. lt gives information on the three-dimensional structure, interaction, and molecular dynamics of the organic molecules in a liquid, solid, gaseous state, and even in-situ biological environment. ...
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Protein-Foundry - Model CCL2 - PFP008 - Recombinant Human Protein Cell - Brochure
Human CCL2, also designated Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF) and JE, chemoattracts mononuclear cells through activation of the G protein-coupled receptor CCR2. The N-terminal glutamine of CCL2 undergoes post-translational modification to pyroglutamic acid. Macrophages and monocytes are the primary producers of CCL2. ...
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Protein-Foundry - Model CXCL2 -PFP030 - Recombinant Human Protein Cell - Brochure
Human CXCL2 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activates the G protein-coupled receptors CXCR2. LPS-stimulated macrophages strongly express CXCL2 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and hematopoietic stem cells and an activator of basophils. ...
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Protein Foundry - Model CCL17 - PFP007 - Recombinant Human Protein Cell - Brochure
CCL17, also known as TARC, is constitutively expressed in the thymus and can be upregulated in peripheral blood mononuclear cells. CCL17 is a ligand for the G protein coupled receptors CCR4 and CCR8, and induces chemotactic migration for T lymphocytes, but not monocytes or granulocytes. ...
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Protein-Foundry - Model CCL5 - PFP020 - Recombinant Human Protein Cell - Brochure
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the infectivity of M-tropic HIV-1 strains. Proteolytic removal of the two ...
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Protein-Foundry - Model CXCL4 -PFP014 - Recombinant Human Protein Cell - Brochure
Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. CXCL4 readily binds to heparin-like molecules and glycoproteins and is a regulator of endothelial and ...
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Protein-Foundry - Model CXCL1 -PFP029 - Recombinant Human Protein Cell - Brochure
Description: Human CXCL1 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activate the G protein-coupled receptor CXCR2. TNF-stimulated epithelial cells strongly express CXCL1 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and an activator of basophils. ...
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Protein-Foundry - Model CX3CL1 - PFP027 - Recombinant Human Protein Cell - Brochure
Human CX3CL1 is a membrane protein consisting of a mucin-like stalk attached to a transmembrane domain containing a C-terminal tail. CX3CL1 is the ligand to the G protein-coupled receptor CX3CR1. CX3CL1 and its receptor have been shown to be a involved in the cellular processes leading to atherosclerosis, where a deletion of the gene specific to the CX3CR1 receptor in transgenic mouse models lead ...
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Xmatrx - Model AS4000RX - Infinity - Fully Automated Molecular Pathology Workstation - Brochure
Xmatrx® Infinity is a fully automated molecular pathology workstation designed to accelerate life sciences research, drug discovery and development. It is an open system that allows simultaneous optimization of 40 assay parameters in a single run. With 40 individually operable and thermally-cyclable slide blocks, it is feasible to perform any slide-based staining assay, including IHC, IF, ...
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BRIM Biotechnology Company Profile - Brochure
BRIM Biotechnology applies integrated and efficient translational science to develop new treatments that help combat and cure disease. Our extensive experience and unique drug development engine, enables us to identify and incubate high-potential novel drug candidates and rapidly deliver partner-ready clinical ...
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ApiJect - Blow-Fill-Seal Temperature Management - Brochure
Over the last 30 years, technology and process advancements have allowed manufacturers to fill-finish a wider range of sterile liquids using BFS, including many biologics and vaccines, small molecules, and other sterile pharmaceuticals. At ApiJect, our engineers have taken these filling enhancements even further by developing proprietary temperature management methods that can potentially enable ...
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