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MedChemExpress - Model Taraxasterol - ...

MedChemExpress - Model Taraxasterol - 1059-14-9

Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3].

Taraxasterol

MCE China：Taraxasterol

Brand：MedChemExpress (MCE)

Cat. No.HY-N1178

CAS：1059-14-9

Purity：99.41%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases.

In Vitro：Taraxasterol (5-18 μg/ml, 1 h) inhibits vascular inflammation in human umbilical vein endothelial cells by activating LXRα [3]. Taraxasterol (2.5-10 μg/ml, 24 h) exhibits anti-inflammatory effects on human osteoarthritic chondrocytes [5]. Taraxasterol (114.68 μM, 24 h) has anti-metastatic effects on prostate cancer cells [6]. Taraxasterol (5-18 μg/ml, 1 h) shows no cytotoxicity to human umbilical vein endothelial cells at concentrations below 15 μg/ml [3].

In Vivo：Taraxasterol (2.5, 5, and 10 mg/kg, i.p., 8 h) has a protective effect against acute lung injury in a lipopolysaccharide (HY-D1056)-induced acute lung injury mouse model[4].

References：

[1]. Zhang X, et al. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 2012 May 7;141(1):206-11. [Content Brief]

[2]. Sang R, Yu Y, Ge B, Xu L, Wang Z, Zhang X. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif Cells Nanomed Biotechnol. 2019;47(1):3929-3937. [Content Brief]

[3]. Zheng F, et al. Anti-inflammatory effects of taraxasterol on LPS-stimulated human umbilical vein endothelial cells[J]. Inflammation, 2018, 41: 1755-1761. [Content Brief]

[4]. San Z, et al. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice[J]. International Immunopharmacology, 2014, 19(2): 342-350. [Content Brief]

[5]. Piao T, et al.Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes. Eur J Pharmacol. 2015 Jun 5;756:38-42. [Content Brief]

[6]. Movahhed M, et al. Anti-metastatic effect of taraxasterol on prostate cancer cell lines. Res Pharm Sci. 2023 Jun 1;18(4):439-448. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。