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MedChemExpress - Model N,N-Dimethylacetamide - 127-19-5

N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease[1][2][3].

N,N-Dimethylacetamide

MCE China：N,N-Dimethylacetamide

Brand：MedChemExpress (MCE)

Cat. No.HY-W042416

CAS：127-19-5

Synonyms：DMAc

Purity：99.93%

Storage：Store at room temperature 3 years

Shipping：Room temperature in continental US; may vary elsewhere.

Description：N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.

In Vitro：N,N-Dimethylacetamide (10-1000 μM, 24 h) inhibits the bactericidal activity of macrophages in RAW 264.7 cells[1]. N,N-Dimethylacetamide (0.1-10 mM, 2 h) inhibits Aβ-induced inflammation in microglia cell lines SIM-A9 and HMC3[2].

In Vivo：N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, intraperitoneally administered) prevents endotoxin-induced preterm birth in C57BL/6 embryo-day (E) 15.5 mice. And the pups were protected from spontaneous abortion in a dose-dependent manner[1]. N,N-Dimethylacetamide (2.1 g/kg/day, intraperitoneally administered) attenuates the clinical and histological features of DSS-induced colitis[3].

References：

[1]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30. [Content Brief]

[2]. Wei ZH, et al. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Sci Rep. 2023 May 1;13(1):7077. [Content Brief]

[3]. Koya JB, et al. FDA-Approved Excipient N, N-Dimethylacetamide Attenuates Inflammatory Bowel Disease in In Vitro and In Vivo Models. Fortune J Health Sci. 2022;5:499-509. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。