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MedChemExpressModel VBY-825 - 1310340-58-9

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VBY-825 is an orally available novel reversible cathepsin inhibitor that has high inhibitory potency against cathepsin B, L, S and V, and possesses anti-tumor, anti-inflammatory and analgesic effects[1][2][3].
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VBY-825

MCE China:VBY-825

Brand:MedChemExpress (MCE)

Cat. No.HY-15958

CAS:1310340-58-9

Purity:99.81%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:VBY-825 is an orally available novel reversible cathepsin inhibitor that has high inhibitory potency against cathepsin B, L, S and V, and possesses anti-tumor, anti-inflammatory and analgesic effects.

In Vitro:VBY-825 (0-300 nM) inhibits both heavy chain isoforms of cathepsin L and cathepsin B with IC50 values of 0.5, 3.3 and 4.3 nM in HUVEC cells[1].

In Vivo:VBY-825 (10 mg/kg, via gavage, once daily, 14 days) reduces pain behaviors in a mouse bone cancer model[2]. VBY-825 inhibits inflammation in mouse models of gout, peritonitis, and arthritis[3].

IC50 & Target:cathepsin K cathepsin S

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References:

[1]. Elie BT, et al. Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie. 2010 Nov;92(11):1618-24.  [Content Brief]

[2]. Umaretiya, et al. Cathepsin Inhibitor, VBY-825, Attenuates Bone Cancer Induced Pain in Mice. The University of Arizona.

[3]. Laura Orellano, et al. Therapeutic potential of VBY-825 in MSU crystal-induced NLRP3 inflammasome activation. The Journal of Immunology. 2024. 212 (1_Supplement): 0957_5533.

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
•   It has a professional experimental center and strict quality control and verification system;
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
•   The biological activity of the products has been verified by the experiments of customers in various countries;
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。