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MedChemExpress - Model Lauric acid - ...

MedChemExpress - Model Lauric acid - 143-07-7

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].

Lauric acid

MCE China：Lauric acid

Brand：MedChemExpress (MCE)

Cat. No.HY-Y0366

CAS：143-07-7

Purity：99.98%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

In Vitro：Lauric acid (0.06-125 μg/ml, 24-72 h) has much stronger antimicrobial activity in P. acnes, S.aureus, and S. epidermidis[1]. Lauric acid (5-50 μM, 24 h) increases glucose uptake and decreases GLUT-1 expression and cellular H2O2 production in insulin-resistant macrophages[2]. Lauric acid (5-50 μM, 24 h) enhances mitochondrial content and mitochondrial biogenesis in the insulin-resistant macrophages[2]. Lauric acid (5-50 μM, 24 h) promotes the gene expressions (PPAR-γ, TFAM and PGC-1α) in THP-1 macrophages[2].

In Vivo：Lauric acid (0.1 μg/μL, i.h., once time) can effectively relieve P. acnes-induced inflammation without detrimental effects on skin cells in mice injected with P. acnes[1]. Lauric acid (1-10 mg/kg, i.v., once time) reduces blood pressure and heart rate in WKY and SHR rats[3].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8. [Content Brief]

[2]. Tham YY, et al. Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages. Mol Biol Rep. 2020 Dec;47(12):9595-9607. [Content Brief]

[3]. Alves NF, et al. Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. Basic Clin Pharmacol Toxicol. 2017 Apr;120(4):348-353. [Content Brief]

Brand introduction:
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•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
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