Companies
MedChemExpress LLC (MCE)
Products
MedChemExpress - Model Isosorbide ...

MedChemExpress - Model Isosorbide mononitrate - 16051-77-7

Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].

Isosorbide mononitrate

MCE China：Isosorbide mononitrate

Brand：MedChemExpress (MCE)

Cat. No.HY-B0642

CAS：16051-77-7

Synonyms：Isosorbide-5-mononitrate

Purity：99.95%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease.

In Vitro：Isosorbide mononitrate (0.5-50 μM, 5 min) inhibited angiogenesis in the chick chorioallantoic membrane dose-dependently[3]. Isosorbide mononitrate (4 ng/mL-5 μg/mL, 24 h) increases HUVECS viability and proliferation and decreases HUVECS apoptosis[4].

In Vivo：Isosorbide mononitrate (200, 600 μg, i.p., daily for 14 days) inhibits angiogenesis, tumour growth and metastasis in mouse tumour model[3]. Isosorbide mononitrate (500 μg/mL, 24 h) up-regulates expressions of vegf-a, kdrl, and pdgfr in zebrafish embryos[4].

References：

[1]. Redfield MM, et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10;373(24):2314-24. [Content Brief]

[2]. Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. [Content Brief]

[3]. Pipili-Synetos E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol. 1995 Sep;116(2):1829-34. [Content Brief]

[4]. Lv H, et al. Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genet Mol Biol. 2020 Jul 24;43(3):20190233. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。