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MedChemExpress - Model Disufenton sodium - 168021-79-2
Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects[1].MCE products for research use only. We do not sell to patients.
Disufenton sodium
MCE China:Disufenton sodium
Brand:MedChemExpress (MCE)
Cat. No.HY-13244
CAS:168021-79-2
Synonyms:NXY-059
Purity:99.97%
Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects.
In Vitro:Disufenton sodium (250 µM, 24 h) reduces the blood brain barrier (BBB) permeability in bovine brain capillary endothelial cells, reduces brain edema and hemorrhagic transformation[3].
In Vivo:Disufenton sodium (28 mg/kg, iv and osmotic pump for 48 h) reduces cerebral infarction volume and improves behavioral dysfunction in marmoset permanent middle cerebral artery occlusion (pMCAO) models[2].
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References:
[1]. Kuroda S, et al. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19(7), 778-787. [Content Brief]
[2]. Marshall JW, et al. NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke, 2001, 32(1), 190-198. [Content Brief]
[3]. Culot M, et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res, 2009, 19(1294), 144-152. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
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• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。