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MedChemExpressModel Disufenton sodium - 168021-79-2

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Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects[1].
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Disufenton sodium

MCE China:Disufenton sodium

Brand:MedChemExpress (MCE)

Cat. No.HY-13244

CAS:168021-79-2

Synonyms:NXY-059

Purity:99.97%

Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects.

In Vitro:Disufenton sodium (250 µM, 24 h) reduces the blood brain barrier (BBB) permeability in bovine brain capillary endothelial cells, reduces brain edema and hemorrhagic transformation[3].

In Vivo:Disufenton sodium (28 mg/kg, iv and osmotic pump for 48 h) reduces cerebral infarction volume and improves behavioral dysfunction in marmoset permanent middle cerebral artery occlusion (pMCAO) models[2].

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References:

[1]. Kuroda S, et al. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19(7), 778-787.  [Content Brief]

[2]. Marshall JW, et al. NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke, 2001, 32(1), 190-198.  [Content Brief]

[3]. Culot M, et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res, 2009, 19(1294), 144-152.  [Content Brief]

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