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Loganin

MCE China：Loganin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0512

CAS：18524-94-2

Synonyms：Loganoside

Purity：99.82%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI).

In Vitro：Loganin (0-50 µM; 24 h) shows significant cytotoxicity to RAW264.7 at high concentrations[3]. Loganin (0-30 µM; 1 h) significantly reduces the production of NO, PGE2, TNF-α, and IL-1β in RAW264.7 macrophages stimulated by LPS (100 ng/ml, 24 h) in a dose-dependent manner, and increases the expression of Nrf2 and HO-1 in a concentration-dependent manner[3]. Loganin (30 µM; 1 h) alleviates LPS-mediated ROS generation in RAW264.7 macrophages[3]. Loganin (0-150 μg/ml; 48 h) reduces the survival rate, migration and invasion ability of Huh7 cells[6].

In Vivo：Loganin (1-10 mg/kg; i.p.; once daily from day 1 to day 28 after SCI) dose-dependently reduced the degree of neurological damage in rats with SCI model[4]. Loganin (80-200 mg/kg; i.g.; 8 weeks of Bleomycin induction, twice a week from week 4 (day 28)) concentration-dependently reduced BLM-induced lung injury in mice[5].

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References：

[1]. Kim MJ, et al. Loganin protects against pancreatitis by inhibiting NF-κB activation. Eur J Pharmacol. 2015 Oct 15;765:541-50.  [Content Brief]

[2]. Tsai WH, et al. Ba-Wei-Di-Huang-Wan through its active ingredient loganin counteracts substance P-enhanced NF-κB/ICAM-1 signaling in rats with bladder hyperactivity. Neurourol Urodyn. 2015 Aug 19.  [Content Brief]

[3]. Park C, et al. Loganin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Response through the Activation of the Nrf2/HO-1 Signaling Pathway in RAW264.7 Macrophages. Biol Pharm Bull.  [Content Brief]

[4]. Huang X, et al. Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling. Toxicon. 2023 Aug 15;232:107202.  [Content Brief]

[5]. Chen L, et al. Protective effect and mechanism of loganin and morroniside on acute lung injury and pulmonary fibrosis. Phytomedicine. 2022 May;99:154030.  [Content Brief]

[6]. CHEN, et al. Loganin inhibits Liver Cancer Cell Proliferation and Metastasis via Blocking Mitogen-Activated Protein Kinase Signaling Pathway. Indian Journal of Pharmaceutical Sciences 86.1 (2024).