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MedChemExpressModel Telitacicept - 2136630-26-5

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Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease[1].
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Telitacicept

MCE China:Telitacicept

Brand:MedChemExpress (MCE)

Cat. No.HY-P99568

CAS:2136630-26-5

Synonyms:RC18

Purity:99.30%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Description:Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease.

In Vivo:Telitacicept (15 and 7.5mpk, i.p.) improves mouse experimental autoimmune encephalomyelitis (EAE) clinical symptoms in MOG35-55 induced EAE model mice[2].

IC50 & Target:(BLyS)/APRIL[1] In Vivo Telitacicept (15 and 7.5mpk, i.p.) improves mouse experimental autoimmune encephalomyelitis (EAE) clinical symptoms in MOG35-55 induced EAE model mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MOG35-55 peptide-induced EAE mice model (6- to 8-week-old, female)[2]

Species:Human

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References:

[1]. Yao X, et, al. Pharmacokinetics analysis based on target-mediated drug distribution for RC18, a novel BLyS/APRIL fusion protein to treat systemic lupus erythematosus and rheumatoid arthritis. Eur J Pharm Sci. 2021 Apr 1;159:105704.   [Content Brief]

[2]. Yuxi Yan, et al. Experimental Autoimmune Encephalomyelitis Animal Models Induced by Different Myelin Antigens Exhibit Differential Pharmacologic Responses to Anti-Inflammatory Drugs. Journal of Immunological Sciences. March 31, 2022.

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