MCE products for research use only. We do not sell to patients.

Lariciresinol

MCE China：Lariciresinol

Brand：MedChemExpress (MCE)

Cat. No.HY-N3405

CAS：27003-73-2

Purity：99.79%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 µM; Ki of 0.046 µM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis。Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity.

In Vitro：Lariciresinol (100-400 µg/mL, 24-72 h) induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway[2]. Lariciresinol (72 h) induces morphological changes, decreases cell growth, survival, proliferation and increases apoptosis in SKBr3 cells[3]. Lariciresinol (10-40 µM, 24 h) inhibits migration-invasion of patient-derived hypertrophic scar fibroblasts via preventing accumulation of collagen[4]. Lariciresinol shows antifungal activity against C. albicans, T. beigelii, and M. furfur with MIC values of 25, 12.5 and 25 μg/mL, respectively[5]. Lariciresinol inhibits α-glucosidase activity with an IC50 value of 6.97 µM and a Ki value of 0.046 µM[6]. Lariciresinol activates insulin signaling leading to glucose transporter 4 (GLUT4) translocation and augmentes glucose uptake in C2C12 cells[6].

In Vivo：Lariciresinol (10 mg/kg, p.o., 3 weeks) displays anti-diabetic activity in Streptozotocin (HY-13753)-treated diabetic mice[6]. Lariciresinol (10-30 mg/kg, i.p., 28 days) inhibits complete Freund's adjuvant-induced arthritis in rats by regulating TGF-β and NF-κB pathways[7]. Lariciresinol (3-15 mg/kg body weight, p.o., daily, 9 weeks (tumor bearing rats); 20-100 ppm, diet, p.o., 5 weeks (E2-maintained ovariectomized athymic mice bearing orthotopic MCF-7 tumors)) inhibits tumor growth and tumor angiogenesis in mammary tumor bearing rats and E2-maintained ovariectomized athymic mice bearing orthotopic MCF-7 tumors[8].

Hot selling product：Peiminine  | Marizomib  | JNK-IN-7  | LLY-283  | SM 16  | Mesitaldehyde  | SU 5402  | Sodium aescinate  | Retinyl acetate  | L-Ornithine

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Nakatsubo T, et al. Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. J Biol Chem. 2008;283(23):15550-15557.  [Content Brief]

[2]. Ma ZJ, et al. Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway. Eur J Pharmacol. 2018 Feb 15;821:1-10.  [Content Brief]

[3]. Soltani M, et al. Investigating the cytotoxic effect of pinoresinol and lariciresinol on breast cancer cell line SKBr3. Modares Journal of Biotechnology, 2020, 11(1): 13-20.

[4]. Sun Y, et al. Lariciresinol Induces Apoptosis and Inhibits Migration-Invasion of Patient-Derived Hypertrophic Scar Fibroblasts via Preventing Accumulation of Collagen. Revista Brasileira de Farmacognosia, 2024, 34(5): 1024-1031.

[5]. Hwang B, et al. Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans. Biochem Biophys Res Commun. 2011 Jul 8;410(3):489-93.  [Content Brief]

[6]. Alam MB, et al. Lariciresinol Displays Anti-Diabetic Activity through Inhibition of α-Glucosidase and Activation and Enhancement of Insulin Signaling. Mol Nutr Food Res. 2022 Jul;66(13):e2100751.  [Content Brief]

[7]. Zhao X, et al. Lariciresinol protects rats from complete Freund's adjuvant induced arthritis in rats via modulation of transforming growth factor-β and nuclear factor kappa B pathway: An in vivo and in silico study. Chem Biol Drug Des. 2023 Jul;102(1):168-176.  [Content Brief]

[8]. Saarinen NM, et al. Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. Int J Cancer. 2008 Sep 1;123(5):1196-204.  [Content Brief]