Companies
MedChemExpress LLC (MCE)
Products
MedChemExpress - Model Sakuranetin - ...

MedChemExpress - Model Sakuranetin - 2957-21-3

Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity[1]. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury[2].

Sakuranetin

MCE China：Sakuranetin

Brand：MedChemExpress (MCE)

Cat. No.HY-N3006

CAS：2957-21-3

Purity：99.94%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.

In Vitro：Sakuranetin (0.1 and 0.3 mM, 0-5 days post inoculation) inhibits fungal mycelium growth in potato dextrose agar[1]. Sakuranetin (0-100 μg/mL, 48 h) inhibits influenza B/Lee/40 virus replication in MDCK cells[3]. Sakuranetin (30 μM, 48 or 72 h) induces melanin synthesis, and increases the expression of Tyr, TRP1, and TRP2 in B16 melanoma cells[4]. Sakuranetin (30 μM, 12-48 h) inhibits phosphorylation of ERK and AKT in B16 melanoma cells[4].

In Vivo：Sakuranetin (20 mg/kg, intratracheal instillation, 10 μL) reduces inflammation, and reduces respiratory system elastance in an mice acute lung inflammation model induced by LPS[2]. Sakuranetin (20 mg/kg, intratracheal instillation) attenuates airway hyperresponsiveness and inflammation in Ovalbumin induced asthma murine model[5].

References：

[1]. Hasegawa M, et al. Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungus. Molecules. 2014 Aug 4;19(8):11404-18. [Content Brief]

[2]. Bittencourt-Mernak MI, et al. Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L217-L230. [Content Brief]

[3]. Kwon DH, et al. Suppression of influenza B virus replication by sakuranetin and mode of its action. Phytother Res. 2018 Dec;32(12):2475-2479. [Content Brief]

[4]. Drira R, et al. Sakuranetin Induces Melanogenesis in B16BL6 Melanoma Cells through Inhibition of ERK and PI3K/AKT Signaling Pathways. Phytother Res. 2016 Jun;30(6):997-1002. [Content Brief]

[5]. Toledo AC, et al. Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. Br J Pharmacol. 2013 Apr;168(7):1736-49. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。