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MedChemExpress - Model Hexamethylene bisacetamide - 3073-59-4

Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice[1][2][3][4][5].

Hexamethylene bisacetamide

MCE China：Hexamethylene bisacetamide

Brand：MedChemExpress (MCE)

Cat. No.HY-124284

CAS：3073-59-4

Synonyms：HMBA

Purity：99.56%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice.

In Vitro：Hexamethylene bisacetamide (2.5-10 mM; 15 days) significantly inhibits the proliferation of SHG-44 cells in a dose-dependent manner, but the inhibitory effect is reversible[2]. Hexamethylene bisacetamide (5-10 mM; 15 days) changes the morphology of SHG-44 cells and increases the degree of cell differentiation[2]. Hexamethylene bisacetamide (1-20 mM; 30-480 minutes) inhibits the activation of MAPK, Akt signaling pathways and NF - κB in TNFα-treated A549 cells[3]. Hexamethylene bisacetamide (5 mM; 2 h-7 days) induces apoptosis through Notch1, Bcl - 2 and p53 signaling pathways in Molt4 cells[4]. Hexamethylene bisacetamide (0.1 mM; 2 h) regulates the expression of neuropeptides through MYH9 and ACTG1 in hypothalamic cells[5].

In Vivo：Hexamethylene bisacetamide (1000 mg/kg intraperitoneal injection; 500-1000 mg/kg intravenous injection; 400 nmoles 2 μL intracerebroventricular injection; 7 days) has an improved effect in mouse obesity model[5].

References：

[1]. Nilsson LM, et al. Muralidharan SV, Demir D, Welin M, Bhadury J, Logan DT, Walse B, Nilsson JA. Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins. Cancer Res. 2016 Apr 15;76(8):2376-83. [Content Brief]

[2]. Li XN, et al. Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells. J Neurosurg. 1996 May;84(5):831-8. [Content Brief]

[3]. Dey A, et al. Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy. Cell Cycle. 2008 Dec;7(23):3759-67. [Content Brief]

[4]. Cecchinato V, et al. Hexamethylene bisacetamide inhibits malignant phenotype in T-ALL cell lines. Leuk Res. 2008 May;32(5):791-7. https://pubmed.ncbi.nlm.nih.gov/17964649/ [Content Brief]

[5]. Park S, et al. HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides. EMBO Mol Med. 2023 Dec 7;15(12):e18024. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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•   It has a professional experimental center and strict quality control and verification system；
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
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