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MedChemExpressModel Formononetin - 485-72-3

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Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].
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Formononetin

MCE China:Formononetin

Brand:MedChemExpress (MCE)

Cat. No.HY-N0183

CAS:485-72-3

Synonyms:Biochanin B; Flavosil; Formononetol

Purity:98.99%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth.

In Vitro:Formononetin is one of the major isoflavonoid constituents isolated from Astragalus membranaceus and has been demonstrated diverse pharmacological benefits. Formononetin possesses anti-angiogenic activity in human colon cancer cells. Formononetin also promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells[1]. Formononetin (25 to 150 μM) markedly decreases the proliferation of endothelial cells stimulated by FGF2[1].

In Vivo:Formononetin dramatically suppresses tumor volumes and the Formononetin-treated group tumor weight are significantly inhibited compared with the vehicle group . Formononetin treatment is well tolerated, and there is no significant difference in weight between vehicle group and formononetin treated groups[1].

IC50 & Target:FGFR2 4.31 μM (IC50)

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References:

[1]. Xiao Yu Wu,et al. Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models. Oncotarget. 2015 Dec 29;6(42):44563-78.  [Content Brief]

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