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MedChemExpress - Model Citrinin - ...

MedChemExpress - Model Citrinin - 518-75-2

Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity[1][2][3][4][5].

Citrinin

MCE China：Citrinin

Brand：MedChemExpress (MCE)

Cat. No.HY-N6746

CAS：518-75-2

Synonyms：NSC 186

Purity：99.72%

Storage：-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.

In Vitro：Citrinin (0.1-1000 nM; 24 h) has neuroprotective effects in glutamate-treated rat cortical neurons (at low doses)[2]. Citrinin (1-10 μg/mL; 6 h) induces late apoptosis of immune cells[3]. Citrinin (1-10 μg/mL; 6 h) increases the rate of Bax/Bcl-2 expression in freshly isolated spleen cells[3].

In Vivo：Citrinin (1-10 mg/kg; Oral gavage; 14 days) has a variety of immunomodulatory effects in mice and may change the normal function of the immune system[3]. Citrinin (2 mg/kg; Oral administration; 3 weeks) has an antitumor effect in a mouse breast cancer model induced by DMBA (HY-W011845)[4].

IC50 & Target：Microbial Metabolite

References：

[1]. de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141. [Content Brief]

[2]. Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41(2):311-9. [Content Brief]

[3]. de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35(1):504-516. [Content Brief]

[4]. Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50(10):3537-47. [Content Brief]

[5]. Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8(21):34525-34533. [Content Brief]

Brand introduction:
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
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