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MedChemExpress - Model Physcion - ...

MedChemExpress - Model Physcion - 521-61-9

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].

Physcion

MCE China：Physcion

Brand：MedChemExpress (MCE)

Cat. No.HY-N0108

CAS：521-61-9

Synonyms：Parietin; Rheochrysidin

Purity：99.10%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells.

In Vitro：Physcion (10 or 20 μM, 48 h) induces apoptosis and autophagy in human nasopharyngeal carcinoma (CNE2 cells)[2]. Physcion (10-40 μM, 24 h) attenuates OGD/R (oxygen-glucose deprivation/reperfusion)-induced neuronal damage and inflammatory response in SH-SY5Y cells[3].

In Vivo：Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model[3]. Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens[4].

IC50 & Target：TLR4

References：

[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [Content Brief]

[2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. [Content Brief]

[3]. Dong X, et al. Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway. Drug Des Devel Ther. 2021 Jan 25;15:277-287. [Content Brief]

[4]. Liu X, et al. Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection. Vet Microbiol. 2023 Apr;279:109664. doi: 10.1016/j.vetmic.2023.109664. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。