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MedChemExpress - Model L-Aspartic acid ...

MedChemExpress - Model L-Aspartic acid - 56-84-8

FromMedChemExpress LLC (MCE)

L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

L-Aspartic acid

MCE China：L-Aspartic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-N0666

CAS：56-84-8

Purity：99.83%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

In Vivo：L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

References：

[1]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. [Content Brief]

[2]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [Content Brief]

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