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MedChemExpress - Model Malabaricone C - ...

MedChemExpress - Model Malabaricone C - 63335-25-1

Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells[1][2][3].

Malabaricone C

MCE China：Malabaricone C

Brand：MedChemExpress (MCE)

Cat. No.HY-N8518

CAS：63335-25-1

Purity：99.61%

Storage：4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells.

In Vitro：Malabaricone C (0.01-1 mM, 3 h) has little cytotoxic activity against wild-type mouse embryonic fibroblasts cells, MEF[1]. Malabaricone C (0.01-1 mM, 3 h) decreases the levels of intracellular triglycerides and decreases lipid accumulation in HepG2 cells[1]. Malabaricone C (1-10 μM, 2 h) inhibits T-cell activation, proliferation, and cytokine production[2]. Malabaricone C (10 μM, 1 h or 24 h) suppresses mitogen-induced activation of cell surface markers, MAPK and NF-κB in lymphocytes[2]. Malabaricone C (4-10 μ M, 24 h) induces apoptosis in MCF-7 cells[3]. Malabaricone C (0-6 μ M, 9 min) increases intracellular Ca2+ levels and activates calpain in MCF-7 cells[3].

In Vivo：Malabaricone C (High-fat diet supplemented with 0.1%, p.o., daily for 8 weeks) reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver in high fat diet-induced obesity mice models[1]. Malabaricone C (10 mg/kg, i.p., a single dose for 24 h) inhibits T-cell activation and cytokine secretion in mice[2].

References：

[1]. Othman MA, et al. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett. 2019;10(8):1154-1158. Published 2019 Jul 3. [Content Brief]

[2]. Patwardhan RS, et al. Malabaricone C, a constituent of spice Myristica malabarica, exhibits anti-inflammatory effects via modulation of cellular redox. J Biosci. 2023;48(2):9. [Content Brief]

[3]. Tyagi M, et al. Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line. Free Radic Res. 2014 Apr;48(4):466-77. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。