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MedChemExpress - Model Micheliolide - ...

MedChemExpress - Model Micheliolide - 68370-47-8

Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].

Micheliolide

MCE China：Micheliolide

Brand：MedChemExpress (MCE)

Cat. No.HY-N0847

CAS：68370-47-8

Purity：99.84%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis.

In Vitro：Micheliolide (0.2-10 μM, 24 h) decreases the proliferation of mesangial cells and the production of MCP-1, TGF-β1, FN increased by a high concentration of glucose (HG) and suppresses the HG-induced degradation of IκBα[1]. Micheliolide (1-10 μM, 18 h) does not affect the growth and apoptosis of Raw264.7. I[2]. Micheliolide (1-10 μM, 3-18 h) inhibits LPS-triggered inflammatory responses in mouse macrophages, dendritic cells (DCs), human monocytic cell line THP-1, human CD14+ monocytes and inhibits LPS-induced NF-κB and PI3K/Akt/p70S6K activation[2][3].

In Vivo：Micheliolide (10 or 20 mg/kg, i.p., a single dose for 2 h) attenuates the secretion of serum cytokines and protects against lung and liver tissue damage in LPS (10mg/kg, i.p., a single dose for 2 h)-challenged mice[2]. Micheliolide (10 or 20 mg/kg, i.p., a single dose for 6 days) enhances the survival rate in mice following lethal septic shock[2]. Micheliolide (30 mg/kg, i.p., every two days for 63 days) reduces swelling of the paws and suppresses the degeneration of articular cartilage in collagen-induced arthritis mice[4].

References：

[1]. Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18(10):13061-77. [Content Brief]

[2]. Qin X, et al. Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge. Sci Rep. 2016 Mar 17;6:23240. [Content Brief]

[3]. Viennois E, et al. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer. Lab Invest. 2014 Sep;94(9):950-65. [Content Brief]

[4]. Xu H, et al. Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis. Mol Med Rep. 2015 Jan;11(1):489-93. [Content Brief]

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