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MedChemExpress - Model Umbelliferone - ...

MedChemExpress - Model Umbelliferone - 93-35-6

Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects inchronic alcohol-fed rats[1][2][3][4].

Umbelliferone

MCE China：Umbelliferone

Brand：MedChemExpress (MCE)

Cat. No.HY-N0573

CAS：93-35-6

Synonyms：7-Hydroxycoumarin; Hydrangin; NSC 19790

Purity：99.67%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.

In Vitro：Umbelliferone (1-50 μM, 12-48 h) induces a dose‑dependent and time‑dependent reduction in HepG2 cells viability[1]. Umbelliferone (0-50 μM, 24 h) results in the appearance of HepG2 cell shrinkage, membrane blebbing, nuclear condensation and apoptotic body formation[1].

In Vivo：Umbelliferone (90 mg/kg, p.o., daily, 5 days) reduces the number of total cells, neutrophils, eosinophils and mononuclear cells in the bronchoalveolar lavage fluid of challenged mice[2]. Umbelliferone (15-30 mg/kg, i.g., daily, 21 days) shows neuroprotective effects on CUMS (chronic unpredictable mild stress)-induced rat model of depression, which is associated with the inhibition of neuronal apoptosis modulated by ROCK/Akt pathway[3]. Umbelliferone (0.05 g/L, p.o., daily, 8 weeks) protects against alcohol-induced liver damage by inhibiting the TLR4 signaling pathway and activating the antioxidant system in rats with liber-decarli liquid diet containing 5% alcohol [4].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Yu SM, et al. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12(3):3869-3873. [Content Brief]

[2]. Vasconcelos JF, et al. Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol. 2009 May 1;609(1-3):126-31. [Content Brief]

[3]. Qin T, et al. Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway. Behav Brain Res. 2017 Jan 15;317:147-156. [Content Brief]

[4]. Sim MO, et al. Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats. Nutr Res Pract. 2015 Aug;9(4):364-9. [Content Brief]

[5]. Luo DD, et al. Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress. Brain Res Bull. 2008 Sep 5;77(1):8-12. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。