Accelerated Biosciences - Human Trophoblast Stem Cells (hTSCs)
We successfully isolated the hTSC from the chorionic villi of unruptured ectopic pregnancies. The chorionic villi develop from the trophectoderm of the embryo, which later becomes the placenta. hTSC’s pre-placental origin mitigates any ethical dilemmas involving the destruction of potential human life.
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hTSCs are pluripotent. hTSCs can differentiate into cells of the three germ layers – Ectoderm, Mesoderm, and Endoderm.
hTSCs are abundant in source. Ectopic pregnancies account for 2% of all pregnancies in industrialized countries, providing a locally abundant source of cells.
hTSCs are fast. One-step induction with all-trans retinoic acid induces differentiation to neural progenitors in 24 hours. One-step induction with bFGF induces differentiation to insulin-secreting pancreatic progenitors in 24 hours.
hTSCs are effective in animal studies. In both acute and chronic Parkinsonian rats, inter-cranial implantation of 1-day RA-induced neural progenitor cells substantially regenerated the dopaminergic nigrostriatal pathway and functionally alleviates behavioral symptoms of Parkinson’s.
The hTSC is an efficient stem cell platform that can significantly accelerate research timelines, thereby, lower expenditures.
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