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membraPure GmbH
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  5. ARACUS - Model Advanced - Amino Acid ...

ARACUS - Model Advanced - Amino Acid Analyzer System

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The utilization of two pumps in the ARACUS "advanced" system enhances analytical efficiency. This upgraded version, derived from the ARACUS "classic," incorporates an extra pump drive. With the ability to concurrently analyze 96 samples within a cooled autosampler, this system stands out. The dual pump configuration allows for independent operations of two fluidic lines - one for the eluent side and the other for the reactive side. This setup markedly improves the signal-to-noise ratio in the chromatogram. Moreover, the adjustable parameters between the eluent and reagent pump drives offer flexibility, enabling the utilization of the reagent OPA (o-phthalaldehyde) for primary amine detection using a fluorescence detector. Additionally, the introduction of ninhydrin allows for quantitative analysis. To prevent cross-contamination, a specific washing routine for the injection valve and syringe pump is implemented.
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Extended configuration of the ARACUS Classic

  • Detectors with maintenance-free LED technology
  • Chloride-free and citrate-free buffer system
  • Small eluent consumption
  • Upgraded two-pump configuration for independent operation of two fluidic lines (eluent side and reactive side)
  • Continous analysis of 96 samples in a cooled autosampler
  • High sensitivity of amino acids

Reliable analysis results for a wide range of applications
Qualitative and quantitative analysis of amino acids is required for a wide range of applications. Our ARACUS systems are designed for use in clinics, quality control, the pharmaceutical and food industry as well as in research. The ARACUS AA analyzers use the most precise and reproducable methodology, with which you can get up to 44 AA with an “Retention time reproducibility (RSD)” of  less than 0.1%. Choose your desired configuration with the aracus lite, classic and advanced – depending on the complexity of your amino acid analyses.

Amino Acid Analyzers for all major lab applications

  • Detectors with maintenance-free LED technology (440 & 570 nm) / no UV/VIS lamp degeneration and lamp exchange
  • Chloride-free and citrate-free buffer system / less aggressive to the components of the liquid handling tubes, fittings and connection
  • Small eluent consumption / about 200 µL/min in analysis mode
  • High sensitivity of amino acids / choice of two sensitivity detector levels
  • Level sensors for eluents / warn the user if needed fluidic volume is too low for planned analysis
  • Easy access to all components of the entire system

Method
Post column derivatization with ninhydrin

Reproducibility of retention time & area
< 0.3 % RSD
ca. 1 % RSD

Detection limit
< 2 nmol/mL

Manual injection port
Upon request each system can be supplied as manual configuration.

High pressure side prime and purge valves in eluent and reagent flow.

Validation documents IQ/OQ and PQ for ARACUS.

For sensitive fluorescence detection of 1° amines with o-phatalaldehyde (OPA) we are providing the suitable fluorescence detector.

It supplies the main unit and eluent box with a protective gas atmosphere by reducing the presence of atmospheric oxygen to enhance the signal to noise ratio.

Active control of fluid volume by weight cell of each bottle. (only available with software aminoPeak).

IVD kit for the qualitative and quantitative determination of amino acids in physiological fluids like human blood and urine for medical diagnostics in combination with the ARACUS IVD advanced.

Manual and automatic peak integration with integrated IQ/OQ procedure for software (only available with software Clarity).

  • method: post column derivatization with Ninhydrin or OPA
  • autosampler: 2 racks, each of them with space for 48 vials, sample cooling dosage in 3 different injection modes: full loop (100 μL), partial loop (5 - 50 μL), microliter pickup (1 - 35 μL)
  • column: stainless steel, cation exchange resin reproducibility of retention time < 1 % RSD, reproducibility of peak area < 3.0 % RSD
  • column oven: 20 - 100 °C, accuracy 0.1 %
  • reactor temperature: 20 - 140 °C
  • spectroscopic detection: measuring range: high, low LED photometers (440 nm + 570 nm), 8 years warranty, flow cell: 10 μL volume, 3 years warranty
  • detection limit: < 40 pmol / 20 µL with Ninhydrin, < 4 pmol / 20 µL with OPA
  • quantification limit: > 100 pmol / 20 µL with Ninhydrin, > 10 pmol / 20 µL with OPA
  • pump system: dual pump reproducibility of low rate: 0.1 % RSD at 100 μL/min, max. pressure: 400 bar | flow rate: 0.01 - 10.00 mL/min
  • maximum operating pressure: 120 bar
  • ready to use kits: kits including eluents, reagent and additional dilution buffer, ammonia adsorber and separation columns for 500 - 1000 runs
  • columns & eluents: Compatible with all columns, operating with all eluents based on different ionic strength (Li, Na, K)
  • control software & data aquisition: Clarity (21 CFR part 11 compliant) or AminoPeak
  • dimensions, weight, power: 1000 x 680 x 360 mm*, 60 kg, 110 - 230 V

*800 mm with opened main unit